摘要
目的:探究阿托西班在宫颈机能不全患者中的应用效果、安全性及对宫颈弹性成像参数的影响。方法:将2021年6月—2023年6月连云港市妇幼保健院收治的80例宫颈机能不全患者根据随机数表法分为两组。对照组的40例患者进行常规宫颈环扎术治疗,观察组的40例患者则在对照组的基础上采用阿托西班进行治疗。比较两组的延长妊娠时间、终止妊娠时间、不良反应发生率、并发症发生率、妊娠结局(足月率、早产率及流产率)、新生儿结局(存活率、肺发育不良率、1 min及5 min Apgar评分)及治疗前后的宫颈弹性成像参数(ECI、HR及EOS)情况。结果:观察组的延长妊娠时间及终止妊娠时间显著长于对照组,差异有统计学意义(P<0.05);两组的不良反应发生率及流产率比较,差异无统计学意义(P>0.05);观察组的并发症发生率、早产率及肺发育不良率显著低于对照组,足月率、存活率、1 min及5 min Apgar评分显著高于对照组,差异有统计学意义(P<0.05);治疗前两组的宫颈弹性成像参数比较,差异无统计学意义(P>0.05);治疗后观察组的ECI及EOS显著低于对照组及治疗前,HR则显著高于对照组及治疗前,差异有统计学意义(P<0.05)。结论:阿托西班在宫颈机能不全患者中的应用效果较好,安全性较高,且可显著改善患者的宫颈弹性成像参数。
Objective:To investigate the application effect and safety of atosiban in patients with cervical incompetence and influence for cervical elastography parameters.Method:80 patients with cervical incompetence admitted to the hospital from June 2021 to June 2023 were randomly divided into two groups.40 cases of control group were treated with routine cervical cerclage surgery,40 cases of observation group were treated with atosiban on the basis of the control group.And the extend pregnancy time,terminate pregnancy time,adverse reactions rates,complications rates,pregnancy outcomes(term rates,premature birth rates and miscarriage rates),neonatal outcomes(survival rates,pulmonary dysplasia rates,1-minute and 5-minute Apgar scores)and cervical elastography parameters(ECI,HR and EOS)before and after the treatment of two groups were compared.Result:The extend pregnancy time and terminate pregnancy time of observation group were significantly shorter than those of control group(P>0.05).The adverse reactions rates and miscarriage rates of two groups were compared,the differences were not statistically significant(P>0.05).The complications rate,premature birth rate and pulmonary dysplasia rate of observation group were significantly lower than those of control group,the term rate,survival rate,1-minute and 5-minute Apgar scores were significantly higher than those of control group(P>0.05).The cervical elastography parameters of two groups before the treatment were compared,the differences were not statistically significant(P>0.05).The ECI and EOS of observation group were significantly lower than those of control group and before the treatment,while the HR was significantly higher than those of control group and before the treatment(P>0.05).Conclusion:The application effect atosiban in patients with cervical incompetence is better,its safety is higher,and it can significantly improve the cervical elastography parameters of patients.
作者
褚楚
王欢
刘梅林
李管
郝彦兰
孟茜
CHU Chu;WANG Huan;LIU Meilin;LI Guan;HAO Yanlan;MENG Qian(Lianyungang Maternal and Child Health Hospital,Lianyungang 222000,China;不详)
出处
《中外医学研究》
2024年第21期123-126,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
