摘要
骨质疏松症(OP)是一种常见的全身代谢性骨病,主要症状特征体现在患者骨量削减、骨微结构变性致使骨脆性增大。减少破骨细胞(OC)活性及增加其凋亡等途径以降低骨吸收是治疗OP的有效手段。相比于国际上主流抗OP药物的不良反应,中草药提取物具有不良作用小、作用靶点广的优势,更适合用于OP的长期预防及治疗。此文通过归纳破骨细胞介导的骨分子吸收机制及常见抗OP的中药提取物单体,为未来抗OP新药的研发提供更多的思路和方案。
Osteoporosis(OP)is a common systemic metabolic bone disease,characterized by bone loss and bone microstructural degeneration,resulting in increased bone fragility.Reducing osteoclast(OC)activity and increasing apoptosis to reduce bone resorption is an effective means to treat OP.Compared with the adverse reactions of mainstream anti-OP drugs in the world,Chinese herbal extracts have the advantages of small side effects and wide targets,and are more suitable for the long-term prevention and treatment of OP.In this paper,the molecular mechanism of osteoclast-mediated bone resorption and the common anti-OP traditional Chinese medicine extract monomer were summarized,which provide more solutions and options for the research and development of new anti-OP drugs in the future.
作者
林玲
向晓东
帅波
卢俊杰
刘菊
LIN Ling;XIANG Xiaodong;SHUAI Bo;LU Junjie;LIU Ju(The First Clinical College,Hubei University of Chinese Medicine,Hubei Province,Wuhan 430000,China;Department of Integrated Traditional and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Province,Wuhan 430000,China;General Medical Department,Wuhan First Hospital Affiliated to Hubei University of Chinese Medicine,Hubei Province,Wuhan 430000,China)
出处
《中国中医药现代远程教育》
2024年第18期91-93,共3页
Chinese Medicine Modern Distance Education of China
基金
国家自然科学基金【No.82174182】
关键词
骨质疏松症
骨流失
淫羊藿
补骨脂
综述
osteoporosis
bone loss
epimedium
fructus psoraleae
review
