摘要
中性粒细胞是心肌缺血再灌注后响应最迅速、数量最丰富的细胞,在启动炎症和组织修复中具有重要作用。本文重点概述了中性粒细胞的生理特点、生物学功能以及不同亚群之间的异质性,总结以中性粒细胞为中心介导的炎症级联反应在心肌缺血再灌注损伤进展中的重要作用,阐述多种靶向中性粒细胞调控的策略及其应用情况和转化前景。
Neutrophils are the most responsive and abundant cells following myocardial ischemia-reperfusion, playing a crucial role in both inflammation and tissue repair. This paper provides a comprehensive summary of the physiological characteristics and biological functions of neutrophils, as well as the heterogeneity among different subpopulations. It also highlights the significant role of neutrophil-mediated inflammatory cascade in myocardial ischemia-reperfusion injury. Additionally, the paper reviews various regulatory strategies targeting neutrophils, discussing their application and potential for translation to clinical practice thus far.
作者
冯玉婷
孙璇
徐标
FENG Yuting;SUN Xuan;XU Biao(Department of Cardiology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,210008,China)
出处
《临床心血管病杂志》
CAS
2024年第7期521-525,共5页
Journal of Clinical Cardiology
基金
国家自然科学基金(No:82070366、82100525)。
关键词
中性粒细胞
心肌缺血再灌注损伤
中性粒细胞胞外诱捕网
中性粒细胞亚群
炎症调控
neutrophils
myocardial ischemia-reperfusion injury
neutrophil extracellular traps
neutrophil subpopulations
inflammation regulation
