摘要
目的探究心脏康复训练对冠心病经皮冠状动脉介入治疗(PCI)术后体适能、心肌酶谱及核因子E2相关因子/血红素氧合酶-1(Nrf2/HO-1)信号通路的影响。方法纳入2022年10月至2023年10月期间于眉山市中医医院接受PCI治疗的冠心病患者100例,根据术后干预方案不同分为观察组(n=52)与对照组(n=48)。对照组予以常规基础干预,观察组在其基础上联合心脏康复训练。比较两组的干预前后的体适能情况、心肌酶谱指标以及Nrf2 mRNA、HO-1 mRNA表达水平;比较两组干预前后的西雅图心绞痛量表(SAQ)以及中国心血管病人生活质量评定问卷(CQQC)评分。结果干预后观察组的心肺适能、柔韧适能、平衡适能较对照组及干预前均改善,差异有统计学意义(t=3.508、2.183、2.660、2.097、1.921,P<0.05);两组干预后的肌钙蛋白I(cTnI)、门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)水平较干预前均较低,且观察组显著低于对照组,差异有统计学意义(t=5.448、11.694、11.020、10.185、8.488,P<0.05);两组干预后的Nrf2 mRNA以及HO-1mRNA水平较干预前均升高,且观察组显著高于对照组,差异有统计学意义(t=41.478、37.970,P<0.05);干预后两组的SAQ、CQQC评分较干预前均升高,且观察组显著高于对照组,差异有统计学意义(t=5.945、20.328,P<0.05)。结论心脏康复对于冠心病PCI术后患者的康复效果显著,能提升体适能水平、改善心肌酶谱指标,可能与调节机体内Nrf2/HO-1信号通路有关。
Objective To explore the effects of cardiac rehabilitation on physical fitness,myocar-dial enzyme profile and Nrf2/HO-1 signaling pathway after PCI.Methods A total of 100 patients with coro-nary heart disease who underwent PCI at Traditional Chinese Medicine Hospital of Meishan from October 2022 to October 2023 were included in the study.They were divided into an observation group(n=52)and a control group(n=48)based on different postoperative intervention programs.The control group received routine basic intervention,and the observation group underwent cardiac rehabilitation training in addition to the routine inter-vention.Physical fitness,myocardial enzyme profile and Nrf2 and HO-1 mRNA levels were compared between the two groups before and after intervention.The SAQ scores of both groups before and after the intervention were compared with CQQC scores.Results After the intervention,the cardiopulmonary fitness,flexibility fit-ness and balance fitness of the observation group showed improvement compared to the control group and before the intervention,and these differences were statistically significant(t=3.508,2.183,2.660,2.097,1.921,P<0.05).Following the intervention,the levels of troponin I(cTnI),aspartate aminotransferase(AST),creatine kinase(CK),creatine kinase isoenzyme(CK-MB)and lactate dehydrogenase(LDH)in both groups were lower than before the intervention,with the observation group showing significantly lower levels compared to the control group.This difference was statistically significant(t=5.448,11.694,11.020,10.185,8.488,P<0.05).The levels of Nrf2 mRNA and HO-1 mRNA in both groups after the intervention increased compared to before the intervention,with the observation group showing significantly higher levels compared to the control group,with a statistical significance(t=41.478,37.970,P<0.05).After the intervention,the SAQ and CQQC scores of both groups were higher than before the intervention,with the observation group showing significantly higher scores compared to the control group.This differ
作者
陈丽梅
龚显田
吴蕾
李珂
CHEN Limei;GONG Xiantian;WU Lei;LI Ke(Department of Cardiovascular Medicine,Traditional Chinese Medicine Hospital of Meishan,Meishan,Sichuan Province,China,620010)
出处
《分子诊断与治疗杂志》
2024年第7期1354-1358,共5页
Journal of Molecular Diagnostics and Therapy
基金
眉山市科技局(kjzd202249)。
关键词
心脏康复
心肌酶谱
冠心病
核因子E2相关因子/血红素氧合酶-1信号通路
Cardiac rehabilitation
Myocardial enzyme profile
Coronary heart disease
Nuclear fac-tor E2-related factor/heme oxygenase-1 signaling pathway
