摘要
目的 分析目前洛阳市人群人乳头瘤病毒(HPV)感染的现状。方法 从LIS系统中收集2020年6月28日至2022年11月30日河南科技大学第一附属医院HPV基因检测的结果以及患者临床资料,剔除信息不全的病例。分析男性与女性之间的感染差异、HPV阳性率、感染亚型及年龄分布等特点。结果 共收集27 639例,其中阳性率女性(27.86%)比男性(23.12%)高,差异有统计学意义(χ^(2)=7.404,P<0.05)。感染率排在前五的亚型依次是男性:HPV16、HPV6、HPV11、HPV39、HPV58;女性:HPV16、HPV52、HPV58、HPV61、HPV51。感染类型均以单重和双重感染为主,男性最多可检出五重感染,女性最多可检出十重感染。男性人群中,年龄最小16岁,最大68岁,各年龄层之间阳性率差异无统计学意义(χ^(2)=10.906,P>0.05);女性人群年龄最小14岁,最大89岁,阳性率较高的两个年龄阶段分别是<20岁(39.80%)和60~69岁(38.20%),各年龄层之间阳性率差异有统计学意义(χ^(2)=259.381,P<0.05)。结论 本次研究结果显示男女人群中HPV感染的优势型别为16和58型,其中女性HPV感染与年龄因素相关。应在本地区加强宣传教育,提高公众对HPV感染的认识和重视程度。
Objective To analyze the status of human papillomavirus(HPV)infection in the population of Luoyang.Methods To collect the results of HPV gene detection and clinical data of patients at the First Affiliated Hospital of Henan University of Science and Technology from the LIS system from June 28,2020 to November 30,2022.Cases with incomplete information were excluded.The differences in infec-tion between men and women,HPV positive rate,infection subtypes,and age distribution were analyzed.Results A total of 27639 cases were collected,with a higher positive rate in women(27.86%)compared to men(23.12%).There was a significant difference in the data(χ^(2)=7.404,P<0.05).The top five subtypes of in-fection in men were HPV16,HPV6,HPV11,HPV39,and HPV58,while in women they were HPV16,HPV52,HPV58,HPV61,and HPV51.The types of infection were mainly single and double infections,with a maximum of five infections detected in men and ten infections detected in women.In the male population,the youngest age was 16 and the oldest age was 68,there was no significant difference in the positive rate among different age groups(χ^(2)=10.906,P>0.05).In the female population,the youngest age was 14 and the oldest age was 89.The two age stages with higher positive rates were<20 years old(39.80%)and 60-69 years old(38.20%).There was a significant difference in the positive rate among different age groups(χ^(2)=259.381,P<0.05).Conclusion The research results show that the most common types of HPV infection in both men and women are type 16 and type 58,with female HPV infection being related to age factors.It is necessary to strengthen publicity and education in this area and raise public awareness and the importance of HPV infection.
作者
刘亚林
李沛
解燕川
康婧祎
陈河涛
LIU Yain;LI Pei;XIE Yanchuan;KANG Jingyi;CHEN Hetao(Central Laboratory,the First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang,Henan,China,471003;Laboratory Department,Xinan County People’s Hospital,Luoyang,Henan,China,471003)
出处
《分子诊断与治疗杂志》
2024年第7期1251-1254,共4页
Journal of Molecular Diagnostics and Therapy
基金
洛阳市医疗卫生指导性科技计划项目(2302008Y)。
