摘要
目的分析北京朝阳区28923例人乳头瘤病毒(HPV)检测结果的感染情况、基因分型及在各年龄段的分布差异,为本地区的宫颈癌(CC)防治及疫苗推广提供参考依据。方法回顾性分析2019年1月至2021年12月在首都医科大学附属北京妇产医院/北京妇幼保健院妇科肿瘤科、计划生育科、妇保妇检科等科室首次就诊且自愿进行多重荧光PCR技术23种HPV基因分型检测的28923例女性患者的人乳头瘤病毒筛查检测结果。结果28923例患者中,检测出HPV感染者11076例,感染率为38.29%;所有HPV感染者中单一型别感染占比24.45%、两重感染占比8.56%、双重以上型别感染占比5.27%;患者年龄从低到高感染率趋势呈U型分布;单一型别感染中高危型HPV(HR-HPV)中最常见的基因型是HPV16型,其次是52、58、53型,单一型别感染中低危型HPV(LR-HPV)中最常见的基因型是HPV81型,其次是42、44、43型;28923例感染者中31~40岁年龄组患者人数最多为8958例(占比31%);检出率小于20岁年龄组最高为55.56%,其次为21~30岁年龄组为42.62%,接下来是大于60岁年龄组为41.88%。结论北京朝阳区总体HR-HPV中感染率最高型别依次是HPV16、52及58型,LR-HPV中感染率最高的型别依次是HPV42、81及44型;年龄上31~50岁组感染率更高,单一HPV感染率高于多重感染,应提高本地区HPV16、52、58型的筛查能力,引起足够重视,有针对性的推广CC疫苗的接种,以便有效降低本地区CC的发生。
Objective To analyze the infection status,genotype distribution,and age-specific differences of 28923 cases of human papillomavirus(HPV)detection results in the Chaoyang District of Beijing,so as to provide a reference basis for the prevention of cervical cancer(CC)and the promotion of vaccines in the local area.Methods A retrospective analysis was conducted for human papillomavirus(HPV)screening test results of 28923 female patients who visited the Department of Obstetrics and Gynecology Oncology,Family Planning Department,and Obstetrics and Gynecology Department of Beijing Obstetrics and Gynecology Hospital/Beijing Maternal and Child Health Hospital affiliated with Capital Medical University from January,2019 to December,2021 and voluntarily underwent multiple fluorescence PCR technology for 23 types of HPV genotyping tests.Results Among 28923 cases,11076 patients were diagnosed with HPV infection,resulting in an infection rate of 38.29%.In terms of all HPV-infected individuals,single-type infections accounted for 24.45%,dual-type infections accounted for 8.56%,and multiple-type infections accounted for 5.27%.The age distribution of patients followed a U-shaped pattern,with the infection rate being lowest at the lowest and highest age groups.In terms of single-type infections,the most common high-risk HPV(HR-HPV)genotypes were HPV16,followed by 52,58,and 53.The most common low-risk HPV(LR-HPV)genotypes were HPV81,followed by 42,44,and 43.Among 28923 infected individuals,the highest number of patients(8958,accounting for 31%)were in the 31-40-year-old age group.The highest detection rate was observed in the under 20-year-old age group,at 55.56%,followed by the 21-30-year-old age group at 42.62%,and then the over 60-year-old age group at 41.88%.Conclusion In the overall HR-HPV infection rate in Beijing Chaoyang area,the highest infection types are HPV16,52,and 58.In LR-HPV,the highest infection types are HPV42,81,and 44.The infection rate is higher in the age group of 31-50 years,and the rate of single HPV infect
作者
韩立灿
王莹莹
翟燕红
乔晨
曹正
HAN Lican;WANG Yingying;ZHAI Yanhong;QIAO Chen;CAO Zheng(Department of Laboratory Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University.Beijing Maternal and Child Health Care Hospital Beijing 100026,China)
出处
《标记免疫分析与临床》
CAS
2024年第1期28-33,51,共7页
Labeled Immunoassays and Clinical Medicine
基金
北京市卫生健康科技成果和适宜技术推广项目-基于电感耦合等离子体质谱技术(ICP-MS)在临床微量元素检测项目上的推广应用(编号:BHTPP2022017)。
