摘要
目的调查北京市海淀区妇女人乳头状瘤病毒(HPV)感染率、感染亚型及感染年龄分布情况,为预防HPV感染提供依据。方法采用荧光定量PCR方法对2017年7月至2019年7月3650例就诊于解放军总医院第四医学中心的女性进行HPV基因亚型检测,17种型别包括15种高危型和2种低危型,分析比较感染年龄、感染程度、感染型别。结果3650例受检者阳性825例,总检出率为22.60%;其中HPV高危型745例,占90.30%(745/825),低危型172例,占20.85%(172/825),高低亚型混合感染92例,占11.15%(92/825);女性HPV感染以单一感染为主,共553例,占67.03%(533/825),多重感染272例,占32.97%(272/825);不同年龄组女性感染HPV的亚型各不相同;总体感染率高的五种亚型从高到底依次为HPV 52、HPV 6+11、HPV 16、HPV 58、HPV 51型。结论北京市海淀区女性HPV感染以HPV 52、HPV 6+11、HPV 16型亚型为主,发病趋势呈年轻化,应采取有效措施,降低HPV感染。
Objective To investigate the infection rate,subtypes,and age distribution of human papillomavirus(HPV)among women in Haidian District,Beijing,and to provide evidence for preventing HPV infection.Method A total of 3650 outpatient women from the Fourth Medical Center of Chinese PLA General Hospital,were checked for 17 HPV DNA types by fluorescence quantitative PCR assay.The HPV infection age distribution of the subjects,HPV infection rate and HPV subtypes were analyzed.Result Among 3650 women,there were 825 cases of HPV infection and the infection rate was 22.60%,including 745 cases of highrisk subtypes and 172 cases of low-risk subtypes,and 92 cases of mixed infection of high and low subtypes,accounting for 11.15%(92/825).Female HPV infection is dominated by single infection,a total of 553 cases,accounting for 67.03%(533/825),and 272 cases of multiple infection,accounting for 32.97%(272/825).Women in different age groups show different subtypes of HPV infection.The top five high-risk HPV infection subtypes were 52,6+11,16,58 and 51 subtypes.Conclusion Female HPV infections in Haidian District of Beijing are mainly HPV 52,HPV 6+11,and HPV 16 subtypes.The incidence trend is younger.Effective measures should be taken to reduce HPV infection.
作者
王海滨
张冬青
赵娇
WANG Haibin;ZHANG Dongqing;ZHAO Jiao(Department of Clinical Laboratory,the Fourth Medical Center,Chinese PLA General Hospital,Beijing,China,100048)
出处
《分子诊断与治疗杂志》
2020年第10期1411-1414,1418,共5页
Journal of Molecular Diagnostics and Therapy
关键词
HPV
基因分型
北京
Human papillomavirus
Genotype
Beijing
