摘要
目的:观察逍遥散加减治疗肝郁脾虚型乳腺癌患者癌症相关性疲乏的临床疗效。方法:根据患者第一次就诊时间顺序,将96例肝郁脾虚型乳腺癌患者随机分为治疗组和对照组各48例,其中对照组治疗过程中脱落2例,共94例患者完成临床试验,其中治疗组48例,对照组46例,所有纳入患者均为放疗、化疗及靶向治疗结束2个月以上。治疗组给予逍遥散加减口服,对照组予以仙鹤草颗粒剂口服,每2周复诊,4周后观察记录癌症相关性疲乏评分及中医症状评分,比较两组治疗前后免疫功能指标情况。结果:两组治疗后癌症相关性疲乏评分较治疗前降低,差异均有统计学意义(P<0.05),治疗组较对照组改善更为显著(P<0.05)。治疗组治疗后肝郁脾虚中医症状评分较治疗前明显降低(P<0.05),并且CD4^(+)、CD8^(+),CD4^(+)/CD8^(+)水平较治疗前明显改善(P<0.05)。结论:逍遥散加减能够改善肝郁脾虚型乳腺癌患者癌症相关性性疲乏,增强患者免疫功能。
Objective:To observe the clinical efficacy of modified Free Wanderer Powder in treating cancerrelated fatigue(CRF)in breast cancer patients of liver qi stagnation and spleen deficiency type.Methods:Ninety-six breast cancer patients of liver qi stagnation and spleen deficiency type were randomly divided into treatment and control groups,each with 48 patients.During the study,two patients from the control group dropped out,leaving 94 patients who completed the clinical trial(48 in the treatment group and 46 in the control group).All enrolled patients had finished radiotherapy,chemotherapy,and targeted therapy for more than two months.The treatment group received modified Free Wanderer Powder orally,while the control group was given Herba Agrimoniae granules.Patients were re-evaluated every two weeks,and cancer-related fatigue scores and TCM symptom scores were recorded four weeks later.Immune function indicators were also compared before and after treatment between the two groups.Results:After treatment,cancer-related fatigue scores in both groups decreased significantly compared to pre-treatment levels(P<0.05),with the treatment group showing more significant improvement(P<0.05).The TCM symptom scores of liver qi stagnation and spleen deficiency in the treatment group significantly decreased post-treatment(P<0.05),and levels of CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)improved significantly compared to pre-treatment levels(P<0.05).Conclusion:Modified free wanderer powder can improve cancer-related fatigue and enhance immune function in breast cancer patients of liver qi stagnation and spleen deficiency type.
作者
胡正军
任广胜
金益峰
靳永杰
于小伟
HU Zhengjun;REN Guangsheng;JIN Yifeng;JIN Yongjie;YU Xiaowei(Shanghai Jiading District Hospital of Traditional Chinese Medicine,Shanghai 201800,China;Shanghai Jiading District Central Hospital,Shanghai 201899,China)
出处
《中医药信息》
2024年第8期52-57,共6页
Information on Traditional Chinese Medicine
基金
上海市嘉定区卫健委中医重点专科建设项目(2020-JDZYYZDZK-01)。
关键词
乳腺癌
癌症相关性疲乏
肝郁脾虚
逍遥散
Breast cancer
Cancer-related fatigue
Liver qi stagnation and spleen deficiency
Free wanderer powder
