摘要
目的:研究布鲁氏菌病致骨关节损伤患者的骨关节功能障碍评分与血清抗体检测指标的相关性.方法:选择2020年5月—2023年4月在我中心进行检测的44例布鲁氏菌病致骨关节损伤患者作为布鲁氏菌病组,同期选择在我中心进行检测没有受到布鲁氏菌感染的健康人群44例作为对照组.2组都采用骨性关节炎功能评分-日本骨科协会(JOA)评分评定患者的骨关节功能障碍,同时送血清到县人民医院检测抗环状胍氨酸多肽抗体和抗Ⅱ型胶原蛋白水平并进行相关性分析.结果:布鲁氏菌病组的骨关节JOA评分与对照组相比显著降低,差异有统计学意义(P<0.05).布鲁氏菌病组的血清抗环状胍氨酸多肽抗体、抗Ⅱ型胶原蛋白含量都显著高于对照组,组间差异有统计学意义(P<0.05).布鲁氏菌病组Pearson分析显示,布鲁氏菌病致骨关节损伤患者的骨关节JOA评分与血清抗环状胍氨酸多肽抗体、抗Ⅱ型胶原蛋白含量存在相关性(P<0.05).在布鲁氏菌病组中,以骨关节JOA评分作为因变量,以血清抗环状胍氨酸多肽抗体、抗Ⅱ型胶原蛋白含量作为自变量,多元logistic回归分析显示,血清抗环状胍氨酸多肽抗体、抗Ⅱ型胶原蛋白含量为影响布鲁氏菌病致骨关节损伤患者骨关节JOA评分的重要因素(P<0.05).结论:布鲁氏菌病致骨关节损伤多伴随血清抗环状胍氨酸多肽抗体、抗Ⅱ型胶原蛋白的高表达,布鲁氏菌病致骨关节损伤患者的骨关节功能障碍评分与血清抗体检测指标存在相关性.
Objective:To study the correlation between bone and joint dysfunction score and serum antibody detection index in patients with bone and joint injury caused by brucellosis.Methods:44 patients with bone and joint injury caused by brucellosis who were tested in our center from May 2020 to April 2023 were selected as the brucellosis group,and 44 healthy people without brucellosis infection who were tested in our center during the same period were selected as the control group.Osteoarthritis function Score-Japanese Orthopaedic Association(JOA)score was used to evaluate the osteojoint dysfunction of patients in both groups.Meanwhile,serum was sent to County People's Hospital to detect the levels of anti-cyclic guanidine polypeptide antibodies and anti-typeⅡcollagen,and correlation analysis was conducted.Results:The bone and joint JOA score of brucellosis group was significantly lower than that of control group,and the difference between groups was statistically significant(P<0.05).The serum anti-cyclic guanidine polypeptide antibody and anti-typeⅡcollagen contents in brucellosis group were significantly higher than those in control group,with statistical significance(P<0.05).Pearson analysis in the brucellosis group showed that there was a correlation between the bone and joint JOA score and the serum anti-cyclic agglutinine polypeptide antibody and anti-typeⅡcollagen content in the patients with brucellosis(P<0.05).In the brucellosis group,the bone and joint JOA score were used as the dependent variable,and serum anti-cyclic guanidine polypeptide antibody and anti-typeⅡcollagen content were used as independent variables.Multiple logistic regression analysis showed that,Serum anti-cyclic guanidine polypeptide antibody and anti-typeⅡcollagen content were important factors affecting bone and joint JOA score in patients with bone and joint injury caused by brucellosis(P<0.05).Conclusion:The bone and joint injury caused by brucellosis is often accompanied by the high expression of anti-cyclic guanidine polypepti
作者
王兵义
刘伟国
任杰
李红梅
马中瑞
WANG Bingyi;LIU Weiguo;REN Jie;LI Hongmei;MA Zhongrui(Department of health laboratory,Minqin county center for disease control and prevention,Wuwei,Gansu 733399;Department of health surveillance,Minqin county center for disease control and prevention;Department of endemic disease prevention and control,Minqin county center for disease control and prevention;Department of orthopaedics,Minqin county people's hospital)
出处
《中国伤残医学》
2024年第10期10-12,16,共4页
Chinese Journal of Trauma and Disability Medicine
