摘要
目的探讨骨肽联合利福喷丁、左氧氟沙星对布鲁氏菌病骨关节损害的治疗效果。方法采用前瞻性研究,选择2017年1月至2021年6月山西省人民医院收治的布鲁氏菌病骨关节损害患者64例,采用随机数字表法分为对照组(32例)、观察组(32例)。对照组给予利福喷丁和左氧氟沙星治疗,观察组在对照组基础上给予骨肽治疗,治疗周期为8周;并于治疗前、后采集患者末梢静脉血。比较两组患者治疗前、后视觉模拟评分法(VAS)、日常生活能力量表(ADL)评分,血清C-反应蛋白(CRP)、降钙素原(PCT)水平,红细胞沉降率(ESR)及血清细胞因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平。结果观察组和对照组患者治疗总有效率分别为90.62%(29/32)、65.62%(21/32),组间比较差异有统计学意义(χ^(2)=5.85,P=0.016)。治疗后,观察组患者VAS评分低于对照组(t=8.29,P<0.001),ADL评分高于对照组(t=6.77,P<0.001);两组患者治疗后VAS评分均低于同组治疗前(t=21.72、15.09,均P<0.001),ADL评分均高于同组治疗前(t=22.49、12.54,均P<0.001)。治疗后,观察组患者CRP、PCT、ESR、TNF-α、IL-6水平均低于对照组(t=8.11、10.75、4.64、5.11、4.55,均P<0.001);两组患者治疗后CRP、PCT、ESR、TNF-α、IL-6水平均低于同组治疗前(t=14.21、21.47、11.21、15.07、9.73,15.50、21.30、7.52、6.78、4.93,均P<0.001)。结论骨肽联合利福喷丁、左氧氟沙星治疗布鲁氏菌病骨关节损害的疗效良好,可明显减轻患者疼痛及细胞炎性反应,提高患者生活质量。
Objective To study the therapeutic effect of bone peptide combined with rifapentin and levofloxacin on bone and joint damage caused by brucellosis.Methods A prospective study was conducted to select 64 patients with brucellosis bone and joint damage admitted to Shanxi Provincial People's Hospital from January 2017 to June 2021.They were randomly divided into a control group(32 cases)and an observation group(32 cases)using a random number table method.The control group was treated with rifapentin and levofloxacin,while the observation group was treated with bone peptide on the basis of the control group,with a treatment period of 8 weeks,and the peripheral venous blood sample was collected before and after treatment.The visual analogue scale(VAS),activity of daily living(ADL)score,serum C-reactive protein(CRP),procalcitonin(PCT),erythrocyte sedimentation rate(ESR),and cytokines[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]levels were compared before and after treatment.Results The total effective rates of treatment in the observation group and the control group were 90.62%(29/32)and 65.62%(21/32),respectively,with statistically significant differences between the groups(χ^(2)=5.85,P=0.016).After treatment,the VAS score of the observation group was lower than that of the control group(t=8.29,P<0.001),and the ADL score was higher than that of the control group(t=6.77,P<0.001).Both groups had lower VAS scores after treatment than before treatment in the same group(t=21.72,15.09,P<0.001),and higher ADL scores than before treatment in the same group(t=22.49,12.54,P<0.001).After treatment,the levels of CRP,PCT,ESR,TNF-α,and IL-6 of the observation group were lower than those of the control group(t=8.11,10.75,4.64,5.11,4.55,P<0.001);the levels of CRP,PCT,ESR,TNF-α,and IL-6 in the two group were lower than these before treatment in the same group(t=14.21,21.47,11.21,15.07,9.73,15.50,21.30,7.52,6.78,4.93,P<0.001).Conclusion The bone peptide combinated with rifapentin and levofloxacin has a good therapeutic effec
作者
申慧彬
申浩
戎杰
Shen Huibin;Shen Hao;Rong Jie(Department of Pharmacy,Shanxi Provincial People's Hospital,Taiyuan 030012,China;Department of Medical Equipment,Shanxi Provincial Hospital of Traditional Chinese Medicine,Taiyuan 030012,China;Department of Case Management,Shanxi Provincial People's Hospital,Taiyuan 030012,China)
出处
《中华地方病学杂志》
CAS
北大核心
2023年第5期405-408,共4页
Chinese Journal of Endemiology
关键词
布鲁杆菌病
骨关节损害
效果
Brucellosis
Bone and joint damage
Therapeutic effect
