摘要
慢性肾衰竭(CRF)患者最常见的一种并发症为钙磷代谢紊乱,其发病率高,易引起心血管事件,导致患者死亡。目前主要通过药物纠正钙磷代谢紊乱,活性维生素D为一线用药,但过度使用会导致高钙血症和高磷血症。磷酸盐结合剂在临床上应用较广泛,疗效佳,但大部分的磷酸盐结合剂都伴随着胃肠道反应。而最新研究的抑制剂EOS789降磷效果显著,且胃肠道反应较少,应用前景广阔。除此之外,联合中医的辨证施治,能有效改善患者药物不良反应,增加患者依从性。透析治疗也尤为重要,且腹膜透析较血液透析效果更好,但最佳纠正钙磷代谢紊乱的透析液钙浓度尚未明确。
One of the most common complications in patients with chronic renal failure(CRF)is the disturbance of calcium and phosphorus metabolism,which has a high incidence and is likely to cause cardiovascular events and lead to death of patients.At present,the disturbance of calcium and phosphorus metabolism are corrected mainly through drugs,and active vitamin D is the first-line drug,but overuse can lead to hypercalcemia and hyperphosphatemia.Phosphate binders are widely used in clinical practice with good efficacy,but most of them are accompanied by gastrointestinal reactions.The newly studied inhibitor EOS789 has significant phosphorus reduction effect and less gastrointestinal reaction,so it has a broad application prospect.In addition,the combination of traditional Chinese medicine syndrome differentiation and treatment can effectively improve patients'adverse drug reactions and increase patients'compliance.Dialysis treatment is also particularly important,and peritoneal dialysis is better than hemodialysis,but the optimal dialysate calcium concentration to correct calcium and phosphorus metabolism disorders is not clear.
作者
刘慧珍
黄廷荣
LIU Huizhen;HUANG Tingrong(Hubei University of Chinese Medicine,Wuhan 430065,China;不详)
出处
《中外医学研究》
2024年第19期177-180,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
慢性肾衰竭
钙磷代谢紊乱
中西医结合
治疗
Chronic renal failure
Disturbance of calcium and phosphorus metabolism
Integration of traditional Chinese and western medicine
Treatment
