摘要
目的探讨银杏叶提取物注射液、阿替普酶静脉溶栓治疗脑梗死患者的疗效。方法选取2021年11月—2023年7月北京市顺义区空港医院收治的86例脑梗死患者为研究对象,通过随机数表法分为两组,各43例。常规组、研究组分别采用阿替普酶静脉溶栓治疗、银杏叶提取物注射液联合阿替普酶静脉溶栓治疗,比较两组治疗结果。结果治疗后,研究组的丙二醛、超氧化物歧化酶水平分别为(6.17±1.06)µmol/L、(120.66±10.73)U/mL,优于常规组,差异有统计学意义(t=5.224、6.834,P均<0.05)。研究组神经功能评分为(4.51±1.07)分,低于常规组的(7.84±1.68)分,差异有统计学意义(t=10.963,P<0.05)。研究组的炎性因子水平和血流动力学指标、脑血流量均优于对照组,差异有统计学意义(P均<0.05)。结论脑梗死患者采取联合药物(银杏叶提取物注射液+阿替普酶静脉溶栓)治疗法,可以改善氧化应激水平,减轻神经功能缺损,提升脑血流量,降低患者炎性因子水平。
Objective To explore the therapeutic effect of ginkgo biloba extract injection and alteplase intravenous thrombolytic therapy on patients with cerebral infarction.Methods A total of 86 patients with cerebral infarction ad-mitted to Shunyi District Airport Hospital,Beijing from November 2021 to July 2023 were selected as the study ob-jects,and were divided into two groups with 43 cases in each by random number table method.The conventional group and the study group were treated with alteplase intravenous thrombolytic therapy and ginkgo biloba extract injec-tion combined with alteplase intravenous thrombolytic therapy,respectively,and the treatment results were compared between the two groups.Results The levels of malondialdehyde and superoxide dismutase in the study group were(6.17±1.06)µmol/L and(120.66±10.73)U/mL,respectively,which were better than those in the conventional group,and the differences were statistically significant(t=5.224,6.834,both P<0.05).The neurological function score of the study group was 4.51±1.07,which was lower than 7.84±1.68 of the conventional group,and the difference was statisti-cally significant(t=10.963,P<0.05).The levels of inflammatory factors,hemodynamic indexes and cerebral blood flow in the study group were better than those in the conventional group,and the differences were statistically significant(all P<0.05).Conclusion Combined therapy(ginkgo biloba extract injection+alteplase intravenous thrombolytic therapy)can improve the expression level of oxidative stress,reduce the degree of neurological impairment,increase cerebral blood flow,and reduce the level of inflammatory factors in patients with cerebral infarction.
作者
李章羽
陈东丽
宋丽云
LI Zhangyu;CHEN Dongli;SONG Liyun(Department of Internal Medicine,Shunyi District Airport Hospital,Beijing,101318 China;Department of Neurology,Shunyi District Airport Hospital,Beijing,101318 China)
出处
《系统医学》
2024年第11期9-12,共4页
Systems Medicine
关键词
银杏叶提取物注射液
阿替普酶静脉溶栓
脑梗死
联合治疗
预后
氧化应激表达
Ginkgo biloba extract injection
Alteplase intravenous thrombolysis
Cerebral infarction
Combination therapy
Prognosis
Oxidative stress expression
