摘要
目的对比分析产程潜伏期间应用间苯三酚(PG)和地西泮(DZP)对初产妇分娩效果的影响。方法回顾性分析2022年1月至2023年12月于杭州市妇产科医院分娩产妇的临床资料。根据产程潜伏期用药方案,分为PG组(PG 80 mg,静脉推注)和DZP组(DZP 10 mg,静脉推注)。比较两组宫颈成熟程度、产程时间、分娩情况(宫口扩张度、产后24 h出血量、分娩方式和宫口全开时间)、新生儿Apgar评分和妊娠相关不良结局。结果研究共纳入162例患者,PG组83例,DZP组79例。PG组宫颈总成熟率显著高于DZP组(P<0.05);第一、第二、第三和总产程时间均短于DZP组(P<0.05)。PG组宫颈扩张度显著大于DZP组(P<0.05),产后24 h出血量和宫口全开时间显著小于DZP组(P<0.05),经阴道分娩率高于DZP组(P<0.05)。两组新生儿1 min、5 min Apgar评分、产妇不良结局发生率和新生儿不良结局发生率差异均无统计学意义(P>0.05)。结论与DZP比较,在潜伏期应用PG可提高宫颈成熟度,加快产程进展,提高经阴道分娩率。
Objective To compare and analyze the effects of application of phloroglucinol(PG)and diazepam(DZP)during the latent phase of labor on the delivery outcome of primiparous women.Methods Clinical data of women who delivered in Hangzhou Obstetrics and Gynecology Hospital from January 2022 to December 2023 were retrospectively analyzed.According to the medication regimen in the latent stage of labor,they were divided into PG group(PG 80 mg,intravenous push)and DZP group(DZP 10 mg,intravenous push).Cervical ripeness,duration of labor,delivery(cervical dilatation,24 h postpartum hemorrhage,mode of delivery,and time to full opening of the uterus),neonatal Apgar score,and pregnancyrelated adverse outcomes were compared between the two groups.Results A total of 162 patients were included in the study,with 83 in the PG group and 79 in the DZP group.The total cervical ripening rate in the PG group was significantly higher than that in the DZP group(P<0.05);the time of the first,second,third,and total labor were all shorter than those in the DZP group(P<0.05).The cervical dilatation in the PG group was significantly greater than that in the DZP group(P<0.05),the amount of postpartum 24 h hemorrhage and time to full opening of the uterine were significantly less than those in the DZP group(P<0.05),and the rate of transvaginal delivery was higher than that of DZP group(P<0.05).The differences in neonatal Apgar scores at 1 min and 5 min,the incidence of adverse maternal outcomes and the incidence of adverse neonatal outcomes between the two groups were not statistically significant(P>0.05).Conclusion Compared with DZP,the application of PG during the latency period can improve cervical ripeness,accelerate the progress of labor,and increase the rate of transvaginal delivery.
作者
施锦金
张晶
何晶
SHI Jinjin;ZHANG Jing;HE Jing(Delivery Center,Hangzhou Women’s Hospital,Hangzhou 310000,China)
出处
《中国药师》
CAS
2024年第7期1178-1183,共6页
China Pharmacist
基金
浙江省医药卫生科技计划项目(2023KY996)。
