摘要
目的:探讨宫腔镜下粘连分离术(TCRA)前1 d的血清雌二醇(E 2)水平与中-重度宫腔粘连(IUA)妊娠结局之间的关系。方法:提取并分析了2018年1月至2019年12月于空军军医大学第二附属医院确诊并接受TCRA的中-重度IUA患者的临床数据。主要结局指标是12个月随访期间的妊娠率,应用多元回归分析、平滑曲线拟合和递归算法分析。结果:在符合纳入标准的288例患者中,有222例符合标准,并最终被纳入分析。多元回归分析结果显示,术前1 d的E 2水平与TCRA后的妊娠率呈负相关(aOR 0.77,95%CI 0.63~0.93,P=0.0074)。递归算法分析结果显示,当术前血清E 2水平小于380.6 pmol/L时,每增加36.7 pmol/L,妊娠率就会降低约20%(aOR 0.78,95%CI 0.67~0.89,P=0.0004)。结论:术前血清E 2水平与中-重度IUA患者的妊娠结局呈负相关。
Objective:To investigate the relationship between serum estradiol(E 2)levels on the day before transcervical resection of adhesion(TCRA)and pregnancy outcomes in moderate-severe intrauterine adhesion(IUA).Methods:Clinical data of patients with moderate-severe IUA diagnosed and received TCRA in the Second Affiliated Hospital of Air Force Medical University from January 2018 to December 2019 were extracted and analyzed.The primary outcome indicator was the pregnancy rate during the 12-month follow-up period.Multiple regression analysis,smoothed curve fitting and recursive algorithm analysis were applied in this study.Results:Among the 288 patients who met the inclusion criteria,222 met the criteria and were finally included in the analysis.The results of multiple regression analysis showed that the E 2 level on the day before surgery was negatively correlated with the pregnancy rate after TCRA(aOR 0.77,95%CI 0.63-0.93,P=0.0074).Recursive algorithm analysis showed that when the preoperative serum E 2 level was less than 380.6 pmol/L,for every increase of 36.7 pmol/L pregnancy rate decreased by approximately 20%(aOR 0.78,95%CI 0.67-0.89,P=0.0004).Conclusions:The results suggest that preoperative serum E 2 levels are negatively associated with pregnancy outcomes in patients with moderate-to-severe IUA.
作者
张琬琳
邱丹儿
汤若楠
肖西峰
王晓红
ZHANG Wanlin;QIU Daner;TANG Ruonan(Reproductive Medical Center,Department of Obstetrics and Gynecology,Tangdu Hospital,The Second Affiliated Hospital of Air Force Medical University,Xi′an Shanxi 710000,China)
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2024年第7期586-590,共5页
Journal of Practical Obstetrics and Gynecology
