摘要
目的分析内分泌激素指标、肿瘤标志物与宫颈癌进展的相关性及其对宫颈癌不良进展的预测价值。方法回顾性分析2020年1月至2023年1月运城市中心院收治的132例宫颈癌患者的临床资料,将宫颈癌患者出现肿瘤复发、转移、肿瘤相关性死亡者视为病情不良进展,作为进展组(n=62),未出现病情进展者作为无进展组(n=70)。分析内分泌功能指标[促卵泡激素(FSH)、促黄体素(LH)、雌二醇、孕酮、睾酮]、血清肿瘤标志物[癌胚抗原(CEA)、鳞状细胞癌抗原(SCCA)、甲胎蛋白(AFP)、糖类抗原(CA)125、CA199]与宫颈癌病情进展的相关性。采用受试者操作特征(ROC)曲线分析内分泌功能指标、血清肿瘤标志物对宫颈癌不良进展的预测价值。结果进展组的国际妇产科联盟(FIGO)分期Ⅲ~Ⅳ期比例、组织学分化中高分化比例、淋巴结转移发生率分别为58.06%、83.87%、27.42%,均高于无进展组(37.14%、67.14%、0),差异均有统计学意义(P<0.05)。进展组的FSH、LH水平分别为(5.13±0.44)、(6.06±0.52)U/L,均高于无进展组[(4.33±0.54)、(4.95±0.61)U/L],进展组雌二醇水平为(109.52±15.08)pmol/L,低于无进展组[(158.81±28.45)pmol/L],差异均有统计学意义(P<0.05);两组孕酮和睾酮水平比较,差异均无统计学意义(P>0.05)。进展组CEA、SCCA、AFP、CA125、CA199水平均高于无进展组,差异均有统计学意义(P<0.05)。LH、FSH水平与血清肿瘤标志物(CEA、SCCA、AFP、CA125、CA199)水平呈正相关(P<0.05),雌二醇水平与血清肿瘤标志物(CEA、SCCA、AFP、CA125、CA199)水平呈负相关(P<0.05);内分泌功能指标(雌二醇、FSH、LH、睾酮、孕酮)中雌二醇水平与宫颈癌病情进展呈负相关(P<0.05),FSH、LH水平与宫颈癌病情进展呈正相关(P<0.05),血清肿瘤标志物水平与宫颈癌病情进展呈正相关(P<0.05)。内分泌功能指标、血清肿瘤标志物联合检测预测宫颈癌不良进展的曲线下面积(AUC)(0.992)、敏�
Objective To analyze the correlation between endocrine hormone indicators,tumor markers and the progression of cervical cancer,and their predictive value for the adverse progression of cervical cancer.Methods Clinical data of 132 cervical cancer patients admitted to Yuncheng Central Hospital from January 2020 to January 2023 were retrospectively selected.Cervical cancer patients with tumor recurrence,metastasis,and tumor-related death were considered as adverse progression were classified into the progression group(n=62),and those who have not progressed were included in the non progression group(n=70).The endocrine function indicators[follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol,progesterone,testosterone],serum tumor markers[carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCCA),alpha-fetoprotein(AFP),carbohydrate antigen(CA)125,CA199]were analyzed,and the progression of cervical cancer,and the predictive value of endocrine function indicators and serum tumor markers for the adverse progression of cervical cancer was analyzed using the receiver operating characteristic(ROC)curve.Results The proportion of International Federation of Gynaecology and Obstetrics(FIGO)stagesⅢ-Ⅳ,the proportion of high differentiation in histological differentiation,and the incidence of lymph node metastasis in the progressive group were 58.06%,83.87%,and 27.42%,respectively,which were higher than those in the non progressive group(37.14%,67.14%,0),and the differences were statistically significant(P<0.05).The levels of LH and FSH in the progression group were(5.13±0.44)and(6.06±0.52)U/L,which were higher than those in the non progression group[(4.33±0.54)and(4.95±0.61)U/L],while the estradiol levels in the progression group were(109.52±15.08)pmol/L,which were lower than those in the non progression group[(158.81±28.45)pmol/L],the differences were statistically significant(P<0.05).There were no statistically significant difference in progesterone,testosterone between the two groups(P>0.05);
作者
周晓妮
张亮
谢亚荣
裴军芳
ZHANG Liang;XIE Ya-rong(Department of Laboratory,Yuncheng Central Hospital,Yuncheng Shanxi 044000,China;Department of CCU,Yuncheng Central Hospital,Yuncheng Shanxi 044000,China)
出处
《临床和实验医学杂志》
2024年第12期1305-1309,共5页
Journal of Clinical and Experimental Medicine
基金
山西省医学重点科学项目(编号:2020XM59)。
关键词
促卵泡激素
促黄体素
雌二醇
宫颈癌
内分泌激素
肿瘤标志物
进展
Follicle stimulating hormone
Luteinizing hormone
Estradiol
Cervical cancer
Endocrine hormones
Tumor markers
Progression
