摘要
目的:探讨血清性激素水平与青春期女孩特发性脊柱侧弯(AIS),以及脊柱侧弯程度和骨密度的关系,分析用性激素鉴别青春期女孩发生AIS概率的可行性、可信度。方法:选择2018年2月至2023年12月我康复中心收治的38例青春期女孩AIS患者(AIS组),另于招募29例同龄的无AIS女孩为对照组。检测血清促黄体生成素(LH)、促卵泡激素(FSH)、孕酮、雌二醇(E2)水平以及脊柱Cobb角、躯干旋转角度、骨密度。分析AIS患者性激素水平与骨密度、脊椎侧弯程度的相关性,以及用性激素水平判断青春期女孩发生AIS概率的价值。结果:AIS组血清LH水平、Cobb角、躯干旋转角度高于对照组(t=4.532、42.835、23.808,P<0.05),E2、骨密度低于对照组(t=2.814、7.082,P<0.05)。AIS患者血清LH与Cobb角、躯干旋转角度呈正相关(P<0.05),与骨密度呈负相关(P<0.05),E2水平与Cobb角、躯干旋转角度呈负相关(P<0.05),与骨密度呈正相关(P<0.05)。E2、LH鉴别青春期女孩发生AIS的曲线下面积为0.690、0.801,联合E2、LH鉴别青春期女孩发生AIS的曲线下面积为0.807,具备鉴别价值(P<0.05),但是与单独E2、LH的鉴别价值相比差异不显著(P>0.05)。结论:性激素水平与青春期女孩AIS发病有关联关系,在AIS的发病机制和病情进展中扮演了重要的角色;通过单独或联合观测E2、LH数据,有助于发现AIS并评估病情严重程度。
Objective:To investigate the relationship between serum sex hormone levels and idiopathic scoliosis(AIS)in adolescent girls,as well as the relationship between sex hormones and the degree of scoliosis and bone mineral density(BMD).The feasibility and credibility of using sex hormones to identify the probability of AIS in adolescent girls were also analyzed.Methods:Thirty-eight adolescent females with AIS(AIS group)treated in our rehabilitation center from February 2018 to December 2023 were selected,and 29 age-matched females without AIS were recruited as the control group.Serum levels of luteinizing hormone(LH),follicle-stimulating hormone(FSH),progesterone,estradiol(E2),Cobb angle,trunk rotation angle,and BMD were measured.The correlation between sex hormone levels and BMD,scoliosis severity in AIS patients,and the value of using sex hormone levels to judge the probability of AIS in adolescent females were analyzed.Results:The serum LH level,Cobb angle,and trunk rotation angle in the AIS group were higher than those in the control group(t=4.532,42.835,23.808,P<0.05),while E2 and BMD were lower than those in the control group(t=2.814,7.082,P<0.05).Serum LH in AIS patients was positively correlated with Cobb angle and trunk rotation angle(P<0.05)and negatively correlated with BMD(P<0.05).E2 levels were negatively correlated with Cobb angle and trunk rotation angle(P<0.05)and positively correlated with BMD(P<0.05).The area under the curve(AUC)for identifying AIS in adolescent females based on E2 and LH was 0.690 and 0.801,respectively.The AUC for identifying AIS in adolescent females based on a combination of E2 and LH was 0.807,which had an identification value(P<0.05),but the difference was not significant compared with the identification value of E2 or LH alone(P>0.05).Conclusion:Sex hormone levels are related to the occurrence of AIS in adolescent females and play an important role in the pathogenesis and progression of the disease.Observation of E2 and LH data alone or in combination can help to identify AIS
作者
韩雪
王士安
张玉华
HAN Xue(Sport Rehabilitation Medical Center,Hebei Institute of Sports Science,Hebei Shijiazhuang 050001,China)
出处
《河北医学》
CAS
2024年第7期1181-1185,共5页
Hebei Medicine
基金
河北省卫生健康委2021年度医学科学研究课题,(编号:20211583)
上海市浦东新区卫生系统优秀青年医学人才培养计划,(编号:PWRq2021-15)。
关键词
特发性脊柱侧弯
性激素
青春期
雌激素
骨密度
Idiopathic scoliosis
Sex hormones
Adolescence
Estrogen
Bone mineral density
