摘要
脑白质高信号(WMH)是多种不同病因引起的脑室周围及半卵圆中心区的脑白质弥漫斑点状或斑片状缺血改变,其代表了白质组成的变化,表明疏水白质纤维束中水分含量的改变。WMH在临床上通常被作为脑小血管病的影像标志。既往研究表明,WMH与认知功能损伤具有高度关联性。大规模基于人群和医院的纵向研究证实了WMH与临床症状之间的相关关系,并证明了大范围WMH与痴呆之间的因果关系。充分的鉴别诊断、评估和管理对任何患者来说都是至关重要的,尤其是早期认知障碍的患者。新的成像技术可能会在MRI可见之前揭示微妙的损伤。
Cerebral white matter hyperintensity(WMH)is a type of ischemic alteration that appears as speckled or patchy areas around the ventricles and in the centrocentral area of the semiovals.This alteration can be caused by various factors and indicates a change in the composition of the white matter in the brain.It suggests an alteration in the water content of the hydrophobic white matter fiber bundles.WMH is commonly used as an imaging marker for cerebral small vessel disease.Previous studies have shown that WMH is highly correlated with cognitive impairment.Large-scale longitudinal studies,both population-based and hospital-based,have confirmed the correlation between WMH and clinical symptoms and demonstrated a causal relationship between large-scale WMH and dementia.Adequate differential diagnosis,evaluation,and management are crucial for patients,especially those with early cognitive impairment.Novel imaging techniques may detect subtle impairments before they become visible on an MRI.The purpose of this review is to offer a comprehensive overview of the relationship between WMH and cognitive function.
作者
章腾
杨素新
严一丹
杨明
刘一辉
符雪涛
许笑天
ZHANG Teng;YANG Suxin;YAN Yidan(Department of Neurology,Affiliated Hospital of Yangzhou University Yangzhou 225002,China)
出处
《临床神经病学杂志》
CAS
2024年第3期226-230,共5页
Journal of Clinical Neurology
关键词
白质高信号
认知功能障碍
痴呆
神经成像
white matter hyperintensity
cognitive impairment
dementia
neuroimaging
