摘要
目的探讨AchR抗体、Titin抗体双阳性的重症肌无力患者的临床特点。方法回顾分析AchR抗体、Titin抗体双阳性的重症肌无力病例(A组)18例,AchR抗体阳性重症肌无力病例(B组)20例。通过患者性别、首次发病年龄、首发临床症状、合并相关抗体情况(ANA抗体、甲状腺抗体)、合并胸腺瘤、新斯的明结果、RNS电生理结果、Osserman分型方面分析。结果收集38例重症肌无力患者,男21例,女17例,年龄58.29±12.99岁,其中A组男9例,女9例,年龄60.28±9.04岁,B组男12例,女8例,年龄56.5±15.76岁。在P=0.05水平上,A、B两组组间性别、发病年龄、合并自身免疫性疾病、胸腺瘤、新斯的明试验阳性、RNS、累及肌肉、眼睑型百分比等各项临床指标无统计学意义。结论对于AchR抗体、Titin抗体阳性和单AchR抗体阳性患者来说,从性别、发病年龄、临床表现、胸腺瘤、合并自身免疫性疾病等方面分析,组间无差异,可认为titin抗体是伴随抗体。抗体检测对于重症肌无力诊治至关重要,分析临床表型、免疫学特点及治疗反应性,可以促使临床医生更好的制订更针对性的治疗方案。
Objective To investigate the clinical characteristics of myasthenia gravis patients with AchR antibody and Titin antibody positive.Methods 18 cases of myasthenia gravis(group A)and 20 cases of myasthenia gravis(group B)with AchR antibody and Titin antibody were retrospectively analyzed.Gender,age of first onset,first clinical symptoms,associated antibodies(ANA antibody,thyroid antibody),associated thymoma,neostigmine results,RNS electrophysiological results,and Osserman typing were analyzed.Results A total of 38 patients with myasthenia gravis were collected,including 21 males and 17 females,aged 58.29±12.99 years.There were 9 males and 9 females in group A,aged 60.28±9.04 years,and 12 males and 8 females in group B,aged 56.5±15.76 years.At the P=0.05 level,there was no statistical significance in gender,age of onset,combination of autoimmune diseases,thymoma,positive neostigmine test,RNS,muscle involvement and percentage of eyelid type between groups A and B.Conclusion For the patients with AchR antibody,Titin antibody double positive and single AchR antibody positive,there was no difference between the groups in terms of gender,age of onset,clinical manifestations,thymoma,and autoimmune diseases,and titin antibody can be considered as a concomitant antibody.Antibody detection is very important for the diagnosis and treatment of myasthenia gravis.The analysis of clinical phenotype,immune characteristics and therapeutic reactivity can facilitate clinicians to make more targeted treatment plans.
作者
刘波
LIU Bo(Department of Neurology,Anyang People’s Hospital,Anyang 455000,Henan Province,China)
出处
《罕少疾病杂志》
2024年第7期119-121,共3页
Journal of Rare and Uncommon Diseases
