摘要
本研究回顾了2017年1月至2020年10月在河南省人民医院神经内科住院,血清抗CV2抗体阳性的46例患者临床资料,年龄(54±15)岁,男女比例1.88∶1,其中26例为副肿瘤神经综合征(PNS),最常见的肿瘤是胸腺瘤、小细胞肺癌、前列腺癌,最常见的PNS包括重症肌无力、亚急性小脑变性、亚急性/慢性感觉运动神经病。20例非PNS见于亚急性/陈旧性脑梗死、帕金森病、阿尔茨海默病等,其中10例颅脑MRI中发现不同程度的脑白质脱髓鞘部分合并脑萎缩。本研究发现抗CV2抗体诊断PNS的阳性预测值为56.5%,相对较弱,其作为伴随抗体可能为巧合,亦可能与其家族成员参与疾病的病理过程有关。
This study reviewed the clinical data of patients who were hospitalized in the Department of Neurology of Henan Provincial People′s Hospital from January 2017 to October 2020.A total of 46 patients with positive serum anti-CV2 antibody were included.The average age of the patients was(54±15)years old,with a male to female ratio of 1.88∶1.Twenty-six patients were diagnosed with paraneoplastic neurological syndrome(PNS).The most malignant tumors were thymoma,small cell lung cancer,and prostate cancer.The most common PNS included myasthenia gravis,subacute cerebellar degeneration,and subacute/chronic sensorimotor neuropathies.Twenty non-PNS patients exhibited subacute/old cerebral infarction,Parkinson′s disease,Alzheimer′s disease,and so on.Among them,brain magnetic resonance imaging(MRI)of 10 cases showed different degrees of white matter demyelination,some of which were accompanied by brain atrophy.The current study found that the positive predictive value of anti-CV2 antibody for the diagnosis of PNS was 56.5%,which was relatively weak.As an accompanying antibody,it may be a coincidence,and it may also be related to the involvement of family members in the pathological process of the diseases.
作者
贾燕
黄月
张杰文
朱明芳
李鹏辉
王丽丽
邵文君
谭蕾蕾
秦亚辉
陈忱
Jia Yan;Huang Yue;Zhang Jiewen;Zhu Mingfang;Li Penghui;Wang Lili;Shao Wenjun;Tan Leilei;Qin Yahui;Chen Chen(Department of Neurology,Henan University People′s Hospital,Zhengzhou,450000,China;Department of Neurology,Henan Provincial People′s Hospital,Zhengzhou,450000,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2021年第27期2170-2172,共3页
National Medical Journal of China
