摘要
目的研究米非司酮联合左炔诺孕酮宫内缓释系统(LNG-IUS)治疗子宫肌瘤(UF)患者的疗效,及对宫动脉(UtA)血流指数、血清肿瘤标志物、金属基质蛋白酶(MMP)-2的影响。方法选择2020年7月至2022年6月间于我院接受治疗的126例UF患者,按随机数表法分为实验组(n=65)和对照组(n=61)。对照组接受米非司酮片治疗,实验组在此基础上放置LNG-IUS。比较两组疗效,血清卵泡刺激素(FSH)、黄体生成素(LH)、孕酮(P)和雌二醇(E2)等性激素水平,搏动指数(PI)、阻力指数(RI)和S/D等UtA血流指数以及血清糖类抗原125(CA125)、MMP-2和血管内皮生长因子(VEGF)等肿瘤相关指标水平。结果治疗后,实验组子宫体积和月经量评分均较对照组降低更明显(P<0.05),FSH、LH、P和E2水平均较对照组降低更明显(P<0.05),PI、RI和S/D均较对照组升高更明显(P<0.05),CA125、MMP-2和VEGF水平均较对照组降低更明显(P<0.05)。结论米非司酮联合LNG-IUS治疗UF患者具有确切疗效,并可有效调节UtA血流灌注和降低肿瘤标志物、MMP-2水平,利于病情向好转归。
Objective To research the efficacy of mifepristone combined with levonorgestrel-releasing intrauterine system(LNG-IUS)on uterine fibroids(UF),and its effects on uterine artery(UtA)blood flow index,serum tumor markers and matrix metalloproteinase-2(MMP-2).Methods 126 UF patients admitted to our hospital from July 2020 to June 2022 were selected,and split as research group(n=65)and control group(n=61)by random number method.The control group received mifepristone tablets therapy,and LNG-IUS were applied in the research group as additional treatment based on mifepristone.Therapeutic effects,sex hormone levels including follicle-stimulating hormone(FSH),luteinizing hormone(LH),progestogen(P)and estradiol(E2),UtA blood flow index including pulsatility index(PI),resistance index(RI)and S/D as well as tumor-relative indicators including carbonhydrate antigen 125(CA125),MMP-2 and vascular endothelial growth factor(VEGF)were compared between 2 groups.Results:After therapy,decrease extent of uterine volume and menstrual blood score were greater in research group than control group(P<0.05),decrease extent of FSH,LH,P and E2 levels were greater in research group than control group(P<0.05),increase extent of PI,RI and S/D were greater in research group than control group(P<0.05),decrease extent of CA125,MMP-2 and VEGF levels were greater in the research group than control group(P<0.05).Conclusion Mifepristone combined with LNG-IUS have significantly effects on UF patients,and could effectively regulate UtA blood perfusion as well as down-regulate tumor marker and MMP-2 levels,which are beneficial for the recovery of disease.
作者
余黎吉
伍丹丹
刘佳
孙境亮
YU Li-ji;WU Dan-dan;LIU Jia;SUN Jing-liang(Gynecological Department of Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000,Fujian Province,China;Obstetrics and Gynecology Department of Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000,Fujian Province,China)
出处
《罕少疾病杂志》
2024年第7期86-88,共3页
Journal of Rare and Uncommon Diseases
关键词
子宫肌瘤
米非司酮
左炔诺孕酮宫内缓释系统
子宫动脉血流指数
肿瘤标志物
Uterine Fibroids
Mifepristone
Levonorgestrel-releasing Intrauterine System
Uterine Artery Perfusion Index
Tumor Markers
