摘要
目的 本研究旨在评估参苓白术散结合穴位贴敷疗法在腹泻型肠易激综合征(irritable bowel syndrome with diarrhea,IBS-D)治疗中的临床效果。方法 选取2022年5月-2023年8月期间就诊于安徽中医药大学第二附属医院脾胃病科门诊与住院部的肠易激综合征腹泻型的患者88例,采用随机数字表法分组为对照组与研究组,各44例。在控制日常饮食与适量运动的前提下,对照组采用盐酸洛哌丁胺治疗,而研究组则应用参苓白术散与穴位贴敷的联合疗法。经过为期28 d的治疗周期,对2组腹泻型肠易激综合征患者的治疗效果进行全面评估。结果 研究组的临床治疗效果在总有效率上明显优于对照组,差异具有统计学意义(P<0.05),其腹胀、排便频率、性状及腹痛程度的改善情况均优于对照组(P<0.05)。经过治疗周期后,2组的血清5-羟色胺(5-HT)以及神经肽Y(NPY)指标均呈现下降趋势,差异具有统计学意义(P<0.05)。在不良反应方面,2组无统计学差异(P>0.05)。对2组中治疗有效的患者进行随访,研究组复发率4.76%(2/42)低于对照组20.00%(7/35)(P<0.05)。结论 参苓白术散联合穴位贴敷治疗腹泻型肠易激综合征具有显著疗效,在改善临床症状和实验室指标方面具有明显优势,且复发率低。
Objective To evaluate the clinical efficacy of Shenling Baizhu San in combination with acupoint application therapy in the treatment of irritable bowel syndrome with diarrhea(IBS-D).Methods A total of 88 patients with IBS-D who visited the Department of Spleen and Stomach Diseases at the Second Affiliated Hospital of Anhui University of Chinese Medicine from May 2022 to August 2023 were selected.They were randomly divided into a control group and a study group,with 44 patients in each group.On the basis of daily diet control and moderate exercise,the control group received loperamide hydrochloride,while the study group received a combined treatment with Shenling Baizhu San and acupoint application.After a 28-day treatment cycle,the treatment effect was comprehensively evaluated in the two groups.Results The clinical treatment effect of the study group was significantly better than that of the control group in terms of overall effective rate(P<0.05),and the improvement in abdominal distension,defecation frequency and character,and degree of abdominal pain was better in the study group than that of the control group(P<0.05).Prior to the treatment intervention,there was no significant difference between the two groups in the baseline levels of serum serotonin(5-HT) and neuropeptide Y(NPY)(P>0.05).After the treatment cycle,the above indicators showed a downward trend in both groups,while the improvement in the study group was more significant,with a statistically significant difference(P<0.05).A follow-up was conducted on patients with effective treatment in the two groups,and the recurrence rate in the study group was 4.76%(2/42),lower than that in the control group(20.00%,7/35)(P<0.05).Conclusion Shenling Baizhu San in combination with acupoint application has a significant therapeutic effect on IBS-D patients,with significant advantages in improving clinical symptoms and laboratory indicators,and with a lower recurrence rate.
作者
陈亮亮
丁义侠
李学军
夏建国
CHEN Liangliang;DING Yixia;LI Xuejun;XIA Jianguo(Second Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230061,China)
出处
《吉林中医药》
2024年第7期817-822,共6页
Jilin Journal of Chinese Medicine
基金
合肥综合性国家科学中心大健康研究新安医学与中医药现代化研究所“揭榜挂帅”项目(2023CXMMTCM017)
安徽省重点研究与开发计划项目(2022e07020023)。
关键词
腹泻型肠易激综合征
参苓白术散
穴位贴敷
疗效观察
irritable bowel syndrome with diarrhea(IBS-D)
Shenling Baizhu San
acupoint application
observation of therapeutic effect
