摘要
目的:观察红花黄色素注射液联合盐酸氟桂利嗪治疗椎基底动脉供血不足性眩晕(VBIV)患者的效果。方法:选取2021年6月至2023年12月该院收治的82例VBIV患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各41例。对照组给予盐酸氟桂利嗪治疗,研究组在对照组基础上联合红花黄色素注射液治疗,比较两组临床疗效,治疗前后中医证候积分、动脉[左椎动脉(LVA)、右椎动脉(RVA)、基底动脉(BA)]血流速度、血液流变学指标[血浆黏度(PV)、纤维蛋白原(FIB)]水平,以及不良反应发生率。结果:研究组治疗总有效率为92.68%(38/41),高于对照组的75.60%(31/41),差异有统计学意义(P<0.05);治疗后,两组眩晕、面色㿠白、肢麻体颤等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组LVA、RVA、BA血流速度均大于治疗前,且研究组大于对照组,差异有统计学意义(P<0.05);两组PV、FIB水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:红花黄色素注射液联合盐酸氟桂利嗪治疗VBIV患者可提高临床疗效,加快椎基底动脉血流速度,降低血液黏稠度,效果优于单纯盐酸氟桂利嗪治疗。
Objective:To observe effects of Safflower yellow injection combined with Flunarizine hydrochloride in treatment of patients with vertebrobasilar insufficiency vertigo(VBIV).Methods:A prospective study was conducted on 82 patients with VBIV admitted to this hospital from June 2021 to December 2023.According to the random number table method,they were divided into control group and observation group,41 cases in each group.The control group was treated with Flunarizine hydrochloride,while the study group was treated with Safflower yellow injection on the basis of that of the control group.The clinical efficacy,the TCM syndrome scores,the arterial blood flow velocity[left vertebral artery(LVA),right vertebral artery(RVA),basilar artery(BA)],the hemorheology indexes[plasma viscosity(PV),fibrinogen(FIB)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 92.68%(38/41),which was higher than 75.60%(31/41)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as vertigo,facial blinking and limb paralysis in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The blood flow velocities of LVA,RVA and BA in the two groups were faster than those before the treatment,those in the study group were faster than those in the control group,and the difference was statistically significant(P<0.05).The levels of PV and FIB in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Safflower yellow injection combined with Flunarizine hydrochloride in the treatment o
作者
戚江丽
QI Jiangli(Department of Neurology of Ganzhou People’s Hospital(Ganzhou Hospital of Southern Hospital),Ganzhou 341000 Jiangxi,China)
出处
《中国民康医学》
2024年第14期94-97,共4页
Medical Journal of Chinese People’s Health
关键词
红花黄色素注射液
盐酸氟桂利嗪
椎基底动脉供血不足性眩晕
血液流变学
动脉血流速度
不良反应
Safflower yellow injection
Flunarizine hydrochloride
Vertebrobasilar artery insufficiency vertigo
Hemorheology
Arterial blood flow velocity
Adverse reaction
