摘要
目的 探讨百令胶囊联合达格列净治疗早期糖尿病肾病(DN)的临床疗效。方法 选取医院2020年2月至2023年2月收治的早期DN患者103例,按治疗方案的不同分为对照组(46例)和观察组(57例)。两组患者均予常规治疗及口服达格列净片控制血糖,观察组患者加服百令胶囊。两组均连续治疗12周。结果 观察组总有效率为89.47%,显著高于对照组的71.74%(P <0.05)。治疗后,两组患者的中医证候积分均显著降低;空腹血糖、餐后2 h血糖、糖化血红蛋白、丙二醛水平均显著降低,超氧化物歧化酶、谷胱甘肽过氧化物酶水平均显著升高;血尿素氮、血清肌酐水平及尿白蛋白与肌酐比值均显著降低,预估肾小球滤过率均显著升高;超敏C反应蛋白、肿瘤坏死因子-α、白细胞介素6水平均显著降低;且观察组患者的上述指标均显著优于对照组(P <0.05)。观察组与对照组患者不良反应发生率相当(3.51%比2.17%,P> 0.05)。结论 百令胶囊联合达格列净治疗早期DN,可改善患者的血糖水平、氧化应激状态、肾功能及临床症状,减轻炎性反应。
Objective To investigate the clinical efficacy of Bailing Capsules combined with dapagliflozin in the treatment of early diabetic nephropathy(DN).Methods A total of 103 patients with early DN admitted to the hospital from February 2020 to February 2023 were selected and divided into the control group(46 cases)and the observation group(57 cases)based on different treatment regimens.The patients in the two groups were given conventional treatment and oral Dapagliflozin Tablets to control blood glucose,on this basis,the patients in the observation group were given Bailing Capsules.Both groups were treated continuously for 12 weeks.Results The total effective rate in the observation group was 89.47%,which was significantly higher than 71.74%in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome scores in the two groups significantly decreased;the fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1C)and malondialdehyde(MDA)levels significantly decreased;the superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)levels significantly increased;the blood urea nitrogen(BUN)and serum creatinine(SCr)levels,and urine albumin/creatinine ratio(UACR)significantly decreased,and estimated glomerular filtration rate(eGFR)significantly increased;the hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)levels significantly decreased(P<0.05).The above indexes in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(3.51%vs.2.17%,P>0.05).Conclusion Bailing Capsules combined with dapagliflozin can improve blood glucose levels,oxidative stress state,renal function and clinical symptoms,and relieve the inflammatory reactions in patients with early DN.
作者
王海燕
陈红燕
唐健
WANG Haiyan;CHEN Hongyan;TANG Jian(Lujiang County People's Hospital,Hefei,Anhui,China 231500)
出处
《中国药业》
CAS
2024年第14期105-108,共4页
China Pharmaceuticals
基金
安徽省中医药传承创新科研项目[2020zcyb17]。
关键词
百令胶囊
达格列净
糖尿病肾病
早期
炎性反应
临床疗效
Bailing Capsules
dapagliflozin
diabetic nephropathy
early
inflammatory reaction
clinical efficacy
