摘要
目的:观察糖肾汤治疗糖尿病肾病(DN)早期(Ⅲ期)的临床疗效。方法:将46例肾阴虚、肾阳虚、阴阳两虚型DN早期患者随机分为治疗组和对照组,每组23例。对照组给予西药常规治疗,治疗组在对照组的基础上联合口服糖肾汤治疗,疗程均为3个月,观察两组治疗前后中医证候积分、尿微量白蛋白/肌酐比(ACR)、血糖及血脂的变化,评价两组临床疗效及安全性。结果:对照组总有效率为56.52%(13/23),治疗组为78.26%(18/23),治疗组优于对照组(P<0.05);对照组临床治愈率为30.43%(11/23),治疗组为47.83%(11/23),治疗组优于对照组(P<0.05)。两组患者治疗后中医证候积分、ACR、空腹血糖、糖化血红蛋白、甘油三酯、胆固醇均较本组治疗前显著下降(P<0.05),且治疗组改善情况显著优于对照组(P<0.05)。两组患者治疗过程中均未出现皮疹、发热、腹泻、恶心、食欲不振等不良反应,血常规、肝功能、心电图检查均未见明显异常。结论:糖肾汤治疗DN早期,在改善患者临床症状,改善肾损伤情况,降低血糖、血脂水平上具有较好的临床疗效。
Objective:To observe the clinical efficacy of Tangshen Decoction in the treatment of diabetic nephropathy(DN)in the early stage(stageⅢ).Methods:Forty-six patients with DN in the early stage of kidney yin deficiency,kidney yang deficiency and kidney yin yang deficiency were randomly divided into treatment group and control group,23 patients in each group.Control group was given conventional western medicine treatment,and the treatment group was treated with Tangshen Decoction on the basis of the control group.The course of treatment was 3 months,observe two groups before and after treatment of TCM syndrome score,urinary microalbumin/creatinine ratio(ACR),blood glucose and the change of the blood lipid level were observed before and after treatment in the two groups,and the clinical efficacy and safety of the two groups were evaluated.Results:The total effective rate of the control group was 56.52%(13/23),and that of the treatment group was 78.26%(18/23).The therapeutic effect of the treatment group was significantly better than that of the control group(P<0.05).The clinical cure rate of the control group was 30.43%(7/23),and that of the treatment group was 47.83%(11/23).The therapeutic effect of the treatment group was significantly better than that of the control group(P<0.05).After treatment,TCM syndrome scores,ACR,fasting blood glucose,glycosylated hemoglobin,triglyceride and cholesterol of the patients in the two groups were significantly lower than those before treatment(P<0.05),and the decline in the treatment group was better than that in the control group(P<0.05).There were no adverse reactions such as rash,fever,diarrhea,nausea,anorexia and other adverse reactions in the two groups during the treatment,and no obvious abnormality was found in blood routine test,liver function and electrocardiogram examination.Conclusion:Tangshen Decoction in the treatment of DN in the early stage has a good clinical effect in improving the clinical symptoms and signs of patients,improving renal injury,controlling blood g
作者
梁家琦
王亚菲
高慧娟
张韦华
翟金婷
张健
谭丽
唐铭
冯兴中
LIANG Jia-qi;WANG Ya-fei;GAO Hui-juan;ZHANG Wei-hua;ZHAI Jin-ting;ZHANG Jian;TAN Li;TANG Ming;FENG Xing-zhong(Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Beijing University of Chinese Medicine,Beijing 100029,China;Tsinghua University Yuquan Hospital,Beijing 100040,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2021年第1期566-569,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
首都卫生发展科研专项项目(No.首发2016-2-2081)
首都临床特色应用研究与成果推广项目(No.Z161100000516076)
北京市医院管理局重点医学专业发展计划(No.ZYLX201812)。
关键词
糖尿病肾病
尿微量白蛋白/肌酐比
糖肾汤
临床疗效
Diabetic nephropathy
Urine microalbumin/creatinine ratio
Tangshen Decoction
Clinical effect
