摘要
目前非酒精性脂肪性肝病在国内外流行趋势不断上升,发病率逐年增加,已严重影响人类生命健康。脂肪自噬是分子伴侣介导的自噬,具有促进脂肪分解、维持肝细胞脂质稳态、缓解肝细胞脂肪变性等作用。脂肪自噬主要包括脂滴分解、脂滴自噬和脂肪酸β氧化三个过程,受关键基因、受体、酶调控。目前中药、西药及饮食运动等干预手段在脂肪自噬研究方面取得了重要进展,为非酒精性脂肪性肝病防治策略提供了新的视角。
Nowadays,the prevalence of nonalcoholic fatty liver disease(NAFLD)is constantly rising in China and globally,and its incidence rate is increasing year by year,which has seriously affected human life and health.Lipophagy is molecular chaperone-mediated autophagy and has the functions of promoting lipolysis,maintaining the lipid homeostasis of hepatocytes,and alleviating hepatocyte fatty degeneration.Lipophagy has three main processes of lipid droplet catabolism,lipid droplet autophagy,and fatty acidβ-oxidation,which are regulated by key genes,receptors,and enzymes.Currently,important advances have been achieved for the intervention methods of traditional Chinese medicine,Western medicine,diet,and exercise in the research on lipophagy,which provides new perspectives for the prevention and treatment strategies for NAFLD.
作者
肖智利
卢晨霞
周丹妮
陈壮壮
肖明中
李晓东
XIAO Zhili;LU Chenxia;ZHOU Danni;CHEN Zhuangzhuang;XIAO Mingzhong;LI Xiaodong(The First Clinical College of Hubei University of Chinese Medicine,Wuhan 430061,China;Department of Hepatology,The Affiliated Hospital of Hubei University of Chinese Medicine,Wuhan 430061,China;Department of Hepatology,Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine,Wuhan 430061,China;Hubei Academy of Chinese Medicine,Wuhan 430074,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2024年第7期1450-1458,共9页
Journal of Clinical Hepatology
基金
国家自然科学基金面上项目(82274352)
湖北省自然科学基金(2020CFA023,2023AFB426,2023AFD129,2023AFD178)。
关键词
非酒精性脂肪性肝病
自噬
治疗学
Non-alcoholic Fatty Liver Disease
Autophagy
Therapeutics
