摘要
心肌梗死是心力衰竭最常见的病因,心肌梗死后可发生心肌重构,从而促进心力衰竭的进程。心肌梗死后心室重构的发生与m^(6)A甲基化密切相关。m^(6)A甲基化是一个可逆的高度动态变化的过程。该过程主要受m^(6)A甲基化正负调控酶的介导,并通过细胞自噬等机制参与心肌梗死后心肌重构的发生。该文主要围绕近年来相关文献进行梳理,首先对m^(6)A甲基化作以简介,然后对m^(6)A甲基化酶调控心肌重构的作用进行介绍,最后从自噬、炎症、细胞凋亡、钙离子稳态、细胞外基质重塑和铁死亡等方面对m^(6)A甲基化调控心肌重构的机制作总结性分析,并讨论了m^(6)A甲基化血清学检测作为诊断心肌梗死后心肌重构的可行性,以期为相关研究提供参考。
Myocardial infarction is the most common cause of heart failure,and myocardial remodeling can occur after infarction,thus contributing to the progression of heart failure.The occurrence of post-infarction ventricular remodeling is closely related to m^(6)A methylation.m^(6)A methylation is a reversible and highly dynamic process.This process is mainly mediated by m^(6)A methylation positive and negative regulatory enzymes and is involved in the occurrence of post-infarction myocardial remodeling through mechanisms such as cellular autophagy.This article mainly reviews relevant literature in recent years.Firstly,a brief introduction is given to m^(6)A methylation,followed by an introduction to the role of m^(6)A methylase in regulating myocardial remodeling.Finally,a summary analysis is conducted on the mechanism of m^(6)A methylation in regulating myocardial remodeling from the perspectives of autophagy,inflammation,cell apoptosis,calcium ion homeostasis,extracellular matrix remodeling,and ferroptosis.The feasibility of using m^(6)A methylation serological detection as a diagnostic tool for myocardial remodeling after myocardial infarction is discussed,in order to provide reference for related research.
作者
解长旭
郭帅杰
陈思琪
张蕾
刘卫红
李思耐
周明学
XIE Changxu;GUO Shuaijie;CHEN Siqi;ZHANG Lei;LIU Weihong;LI Sinai;ZHOU Mingxue(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Beijing Institute of Traditional Chinese Medicine,Beijing 100010,China)
出处
《中国动脉硬化杂志》
CAS
2024年第7期613-620,共8页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(82274287)
北京市自然科学基金项目(7232266)。
关键词
m^(6)A甲基化
心肌梗死
心肌重构
心力衰竭
m^(6)A methylation
myocardial infarction
myocardial remodeling
heart failure
