摘要
目的 对丹黄祛瘀胶囊治疗慢性盆腔炎(SPID)进行药物经济学评价,以期为优化临床药物治疗方案和合理选择药物提供理论参考依据。方法 从卫生体系角度出发,构建丹黄祛瘀胶囊治疗SPID的决策树模型,以通过查询药智网获取的药品成本和检索文献得出的数据计算两种干预方案成本,并根据1篇已发表的Meta分析所得出的效果指标,对丹黄祛瘀胶囊联合抗生素vs.单用抗生素干预SPID的经济性进行评价,最后采用敏感性分析验证增量成本-效果比值(ICER)的稳定性。结果 患者治疗28 d后,丹黄祛瘀胶囊组所获得的效果优于对照组,但使用成本也高于对照组,两组的ICER值为2 324.06,即与单用抗生素的方案比较,使用丹黄祛瘀胶囊联合抗生素治疗SPID每多使1例患者的盆腔包块消失需多花费2 324.06元,ICER值小于2022年我国人均可支配收入的16%,本研究结果经过敏感性分析验证较为稳健。结论 假设将国家统计局最新提供的2022年人均可支配收入数据作为患者的意愿支付阈值,可以得出丹黄祛瘀胶囊联合抗生素治疗在使SPID患者盆腔包块消失方面比单独使用抗生素更具有经济学优势。
Objective A pharmacoeconomic evaluation of Danhuang Quyu Capsules for the treatment of chronic pelvic inflammatory disease(SPID) was conducted to provide a theoretical reference basis for clinical optimization of drug treatment regimens and rational drug selection.Methods In this study,we construct a model for the treatment of SPID with Danhuang Quyu Capsule from a health system perspective.To calculate the cost of the two intervention regimens with the cost of drugs obtained by querying the Pharmaceutical Intelligence Network and the data derived from searching the literature,and to evaluate the economics of Danghuang Quyu Capsules in combination with antibiotics versus antibiotics alone for the intervention of SPID on the basis of the effect metrics from 1 published meta-analysis,and finally to validate the stability of the incremental cost-effectiveness ratios(ICER) by using sensitivity analyses.Results After 28 days of patient treatment,the effect obtained in the Danhuang Quyu Capsule group was better than the control group,but the cost of use was also higher than the control group,The ICER value for the two groups was 2 324.06,compared with the conventional therapy alone regimen,The use of Danhuang Quyu capsules combined with antibiotics for the treatment of chronic pelvic inflammatory disease requires an additional cost of 2 324.06 yuan for each additional patient's pelvic mass disappearance,with an ICER value less than 16% of our per capita disposable income in 2022.The results of this study were validated by sensitivity analysis to be robust.Conclusion Assuming the latest disposable income per capita data provided by the National Bureau of Statistics for 2023 as the patient's willingness-to-pay threshold,it can be concluded that Danhuang Quyu Capsules combined with antibiotic treatment has economic advantages over antibiotics alone in making pelvic mass disappear in SPID patients.
作者
王晓燕
崔鑫
谢雁鸣
WANG Xiao-Yan;CUI Xin;XIE Yan-Ming(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国药物经济学》
2024年第5期36-41,共6页
China Journal of Pharmaceutical Economics
基金
国家中医药管理局2021岐黄学者支持项目(国家中医药人教函[2022]6)
谢雁鸣全国名老中医药专家传承工作室建设项目(国家中医药人教函[2022]75)。
关键词
丹黄祛瘀胶囊
慢性盆腔炎
药物经济学评价
抗生素
Danhuang Quyu Capsules
Chronic pelvic inflammation
Pharmacoeconomic evaluation
Conventional antibiotics
