摘要
溃疡性结肠炎(ulcerative colitis,UC)是以弥漫性黏膜炎症为病理特征,腹痛腹泻、黏液脓血便及里急后重为临床症状的免疫介导疾病,由于病因复杂、治疗困难、预后不良,已被世界卫生组织列为现代难治性疾病之一。微小非编码RNA(microRNA,miRNA)可通过调控基因表达,参与细胞生长、分化、发育等多种生物学过程。研究证明,miRNA通过肠黏膜屏障功能障碍、肠道菌群失调和免疫细胞过度分化等多种途径参与UC的发病进程,有望成为临床治疗UC的新靶点。为了更好地了解miRNA在UC发病机制中的作用,同时为UC的诊断及治疗提供新的研究方向,本文就近年miRNA与UC发病机制的相关性、miRNA作为UC生物标志物的潜力及miRNA在UC中的治疗策略进行综述。
Ulcerative colitis(UC) is a chronic immune-mediated disease characterized by diffuse mucosal inflammation and clinical symptoms of abdominal pain,diarrhea,mucopurulent bloody stool and tenesmus.Due to its complex etiology,difficult treatment and poor prognosis,UC has been listed as one of the modern refractory diseases by the World Health Organization.MicroRNAs(microRNAs) regulate various biological processes such as cell growth,differentiation,and development by regulating gene expression.Studies have shown that miRNA is involved in the pathogenesis of UC through various pathways such as intestinal mucosal barrier homeostasis disorder,intestinal flora imbalance and excessive differentiation of immune cells,and is expected to become a new target for clinical treatment of UC.In order to better understand the role of miRNA in the pathogenesis of UC and provide new research directions for the treatment of UC,this article reviews the correlation between miRNA and the pathogenesis of UC,the potential of miRNA as a biomarker of UC,and the treatment strategies of miRNA in UC in recent years.
作者
刘轩
冯翠娟
王一强
李芳
LIU Xuan;FENG Cuijuan;WANG Yiqiang;LI Fang(Gansu Health Vocational College,Lanzhou 730000,Gansu,China;Hunan University of Medicine,Huaihua 418000,Hunan,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
北大核心
2024年第8期917-929,共13页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
甘肃省自然科学基金项目(22JR5RA590,23JRRA1369)
甘肃省教育科技创新项目(2022A-064,2023A-297)。
