摘要
目的探讨血小板功能指标(血小板计数、平均血小板体积、血小板体积分布宽度)检测对阿司匹林在老年IS二级预防中的预测价值。方法选取2020年3月至2022年3月新疆维吾尔自治区人民医院192例IS患者,所有患者均接受规范化IS治疗,并给予阿司匹林二级预防,对比治疗前、治疗1年后患者血小板功能指标。观察老年IS患者阿司匹林二级预防效果,依据1年内IS复发情况将其分为复发组与未复发组,对比两组基线资料及血小板功能指标,建立Logistic回归模型筛选IS复发的影响因素,绘制受试者工作曲线(ROC)分析治疗前血小板功能指标对老年IS复发的预测价值。结果治疗1年后,患者血小板计数、平均血小板体积、血小板体积分布宽度低于治疗前(P<0.05);随访1年,192例老年IS患者中复发32例,占16.67%;复发组治疗前血小板计数高于未复发组,平均血小板体积、血小板体积分布宽度>未复发组(P<0.05);经Logistic回归分析,结果显示,血小板计数、平均血小板体积、血小板体积分布宽度是老年IS复发的危险因素(OR>1,P<0.05);ROC结果显示,血小板计数、平均血小板体积、血小板体积分布宽度预测老年IS患者复发的AUC=0.715、0.701、0.704,具有一定预测价值,联合检测预测价值更高(AUC=0.808)。结论血小板功能指标对阿司匹林在老年IS二级预防效果具有一定预测价值,能够对患者进行风险分层,指导个性化治疗。
Objective To explore the predictive value of platelet function indexes(platelet count,average platelet volume and platelet volume distribution width)in the secondary prevention effect of aspirin in elderly patients with(i schemic stroke,IS).Methods One hundred and ninety-two patients with IS stroke in People's Hospital of Xinjiang Uygur Autonomous Region from March 2020 to March 2022 were enrolled.All patients received standardized treatment of IS stroke and were given aspirin secondary prevention.The platelet function indexes of patients before and after treatment for one year were compared.To observe the secondary prevention effect of aspirin in elderly patients with IS stroke,and divide them into recurrence group and non-recurrence group according to the recurrence of IS stroke within one year.By comparing the baseline data and platelet function indexes of the two groups,a Logistic regression model was established to screen the influencing factors of IS stroke recurrence,and the working curve(ROC)of the subjects was drawn to analyze the predictive value of platelet function indexes before treatment for the recurrence of IS stroke in the elderly.Results After one year of treatment,the platelet count,average platelet volume and platelet volume distribution width were lower than those before treatment(P<0.05).After a one-year follow-up,32 of 192 elderly patients with IS recurred,accounting for 16.67%.Before treatment,the platelet count in relapse group was higher than that in relapse group,and the average platelet volume and platelet volume distribution width were higher than those in non-relapse group(P<0.05).Logistic regression analysis showed that platelet count,average platelet volume and platelet volume distribution width were risk factors for the recurrence of IS in the elderly(OR>1,P<0.05).The ROC results show that the AUC=0.715,0.701 and 0.704 of platelet count,average platelet volume and platelet volume distribution width in predicting the recurrence of elderly patients with IS have certain predictive va
作者
王儒彬
马筱洁
邱进
陈伟
Wang Rubin;Ma Xiaojie;Qiu Jin;ChenWei(Department of Blood Transfusion,People's Hospital of Xinjiang Uygur Autonomous Region,Uygur 830000,China)
出处
《脑与神经疾病杂志》
CAS
2024年第7期458-462,共5页
Journal of Brain and Nervous Diseases
基金
新疆维吾尔自治区自然科学基金资助项目(2022D01C637、2022DOIC638)。
