摘要
目的探讨建立模拟临床的猪腹壁切口疝模型方法及其可行性。方法入组36只实验猪,采用开放手术切除腹白线并保留腹膜的方式建立猪腹壁切口疝模型,术后每周观察猪腹部隆起和猪的生长情况,确认腹壁切口疝形成时间。于造模术后3个月行腹腔镜联合开腹手术,测量腹壁腱膜缺损大小(缺损长径、短径、面积)、确诊切口疝形成的则行疝环单纯缝合修复。修复术后每周观察腹壁切口疝复发情况,验证腹壁切口疝模型能否模拟临床切口疝的病理生理。结果造模后,36只猪均活动良好,无死亡。所有猪造模后生长情况良好。36只猪在造模术后1个月左右均出现腹部隆起,触诊形成腹壁切口疝。均于造模术后3个月时行腹腔镜联合开腹手术下疝环单纯缝合修复术,所有猪在修复术后1个月左右(平均25 d)出现疝复发,腹壁疝造模均成功。其成模时的疝环长径、疝环短径、疝环面积大于造模时的腹壁缺损长径、缺损短径及缺损面积,差异均有统计学意义(P<0.05)。结论采用本文的造模方法可以建立有效而稳定、无自愈倾向能模拟临床切口疝病理生理的猪腹壁切口疝模型。
Objective To investigate the method of establishing a porcine abdominal wall incisional hernia model that simulates the clinical situation and its feasibility.Methods A total of 36 experimental pigs were enrolled,and a porcine abdominal wall incisional hernia model was established by openly removing linea alba and preserving the peritoneum.The abdominal bulge and growth of the pigs was observed every week after the operation,and the formation time of abdominal wall incisional hernia was determined.Laparoscopic combined with open surgery was performed at 3 months after modeling,and the size of the abdominal wall aponeurosis defect was measured(long diameter,short diameter and area of the defect).In experimental pigs with incisional hernias,the hernia ring was repaired using simple suture.Recurrence of abdominal wall incisional hernia was observed weekly after repair.To verify whether the model of abdominal incisional hernia can simulate the pathophysiology of clinical incisional hernia.Results After modeling,all 36 pigs moved well and did not die.All the pigs grew well after modeling,and all 36 pigs developed abdominal bulges and abdominal wall incisional hernias on palpation about 1 month after modeling.The hernia ring was repaired with simple suture under laparoscopic combined with open surgery at 3 months after modeling,and all pigs showed hernia recurrence about 1 month after repair(average 25 d),and the abdominal wall hernia modeling was successful.The long diameter,the short diameter,and the area of the hernia ring at the time of modeling were greater than those of the abdominal wall defect,and the differences were statistically significant(P<0.05).Conclusion An effective and stable model of pig abdominal wall incisional hernia can be established by using the modeling method presented in this paper.It can simulate the pathophysiology of clinical incisional hernias without self-healing tendencies.
作者
仲洁
逯景辉
林振华
程文悦
代京
张剑
刘成虎
Jie Zhong;Jinghui Lu;Zhenhua Lin;Wenyue Cheng;Jing Dai;Jian Zhang;Chenghu Liu(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Department of Anorectal Surgery,the Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital),Shanghai 200003,China;Department of General Surgery,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China;Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection,Jinan 250101,Shandong,China)
出处
《中华疝和腹壁外科杂志（电子版）》
2024年第2期168-172,共5页
Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition)
基金
国防科技卓越青年科学基金(2019-JCJQ-ZQ-002)。
关键词
腹壁切口疝
模型
动物
模拟临床
Abdominal wall incisional hernia
Model
animal
Clinical imitation
