摘要
为评价卡洛芬注射液与泰拉霉素注射液联用治疗牛呼吸道疾病(bovine respiratory disease,BRD)的效果,并确定合理的给药剂量,试验选择64头患呼吸道疾病的牛,随机分为A、B两组,每组32头,其中A组皮下注射给予泰拉霉素注射液(推荐剂量2.5 mg/kg·bw),同时肌内注射给予卡洛芬注射液(II期临床试验确认剂量1.4 mg/kg·bw);B组只皮下注射给予泰拉霉素注射液(推荐剂量2.5 mg/kg·bw)。所有试验牛各种药均只给予1次。试验期间观察记录各组牛的临床症状,并对其进行评分;通过对各试验牛的炎症因子、致病菌、特定病原抗原/抗体的检测,评价卡洛芬注射液对牛呼吸道疾病的辅助治疗效果。试验结果显示,相比于单独使用泰拉霉素注射液,卡洛芬注射液与泰拉霉素注射液联用治疗BRD可以在更短时间内消除牛体内病原菌感染带来的炎症反应;泰拉霉素注射液单独使用或与卡洛芬注射液联用治疗BRD,给药3 d病牛的血清PCT浓度均明显下降(P<0.05),但两药联用的下降速度更加显著(P<0.05)。结果表明,临床上推荐卡洛芬注射液与泰拉霉素注射液联用,皮下注射,一次量为1.4 mg/kg·bw,可有效辅助治疗牛呼吸道疾病。
The trial was designed to evaluate the efficacy of carprofen injection combined with telamycin injection in the treatment of bovine respiratory disease(BRD)and to determine the appropriate dose to administer.Six-four cattle with BRD,randomly divided into 2 groups,groups A and B,with 32 cows each,among them,group A was administered subcutaneously telamycin injection(recommended dose 2.5 mg/kg·bw)and carprofen injection(phase II confirmed dose 1.4 mg/kg·bw),group B was administered subcutaneously telamycin injection(recommended dose 2.5 mg/kg·bw).All drugs were given only once in all test cattle.The clinical symptoms of each group were recorded during the trial and scored it;the adjuvant treatment efficacy of carprofen injection on bovine respiratory diseases was evaluated by the detection of inflammatory factors,pathogenic bacteria and specific pathogen antigens/antibodies in each test cattle.The results showed that carprofen injection combined with thalamycin injection to treat BRD could eliminate the inflammatory response from pathogen infection in cattle in a shorter time than thalamycin injection alone;Using thalamycin injection alone or in combination with carprofen injection for BRD,the serum PCT concentration in sick cattle decreased significantly(P<0.05),but the decrease in the two drugs was more significant(P<0.05).The results showed that carprofen injection is clinically recommended in combination with telamycin injection,one dose,1.4 mg/kg·bw,which can effectively assist in the treatment of bovine respiratory diseases.
作者
刘静
王玉欣
宋婷婷
耿智霞
贾兴
郭李珉
刘欣
魏占勇
曹兴元
LIU Jing;WANG Yu-xin;SONG Ting-ting;GENG Zhi-xia;JIA Xing;GUO Li-min;LIU Xin;WEI Zhan-yong;CAO Xing-yuan(Hebei Yuanzheng Pharmaceutical Co.,Ltd.,Shijiazhuang 050041,China;Hebei Technology Innovation Center of Veterinary Drugs,Shijiazhuang 050041,China;China Agricultural University,Beijing 100083,China)
出处
《中国兽药杂志》
2024年第6期47-57,共11页
Chinese Journal of Veterinary Drug
关键词
卡洛芬
牛呼吸道疾病
临床疗效
carprofen
dairy cow
bovine respiratory disease
clinical efficacy
