摘要
目的目的探讨手术联合化疗对神经母细胞瘤患儿免疫功能的影响。方法方法将98例神经母细胞瘤患儿根据治疗方式的不同分为对照组(n=48)和观察组(n=50)。对照组患儿采取手术治疗,观察组患儿采取化疗联合手术治疗。比较两组患儿血清肿瘤标志物水平、免疫球蛋白水平、细胞免疫指标以及不良反应发生率。结果结果治疗后,两组患儿基质金属蛋白酶2(MMP2)、基质金属蛋白酶1(MMP1)、血管内皮生长因子(VEGF)水平均较治疗前降低,且观察组患儿MMP2、MMP1、VEGF水平均低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患儿免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)水平均较治疗前降低,但观察组患儿IgA、IgG、IgM水平均高于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患儿总T淋巴细胞(TTL)水平均较治疗前降低,辅助性T淋巴细胞(THL)、抑制性T淋巴细胞(TSL)、自然杀伤(NK)细胞水平均较治疗前升高,观察组患儿TTL、THL、TSL、NK细胞水平均高于对照组,差异均有统计学意义(P﹤0.05)。两组患儿各不良反应发生率比较,差异均无统计学意义(P﹥0.05)。结论结论手术联合化疗治疗小儿神经母细胞瘤,可改善患儿免疫功能,抑制肿瘤浸润及转移。
Objective To investigate the effect of surgery combined with chemotherapy on immune function in chil-dren with neuroblastoma.Method A total of 98 children with neuroblastoma were divided into control group(n=48)and observation group(n=50)according to different treatment methods.The control group received surgery,and the observa-tion group received chemotherapy combined with surgery.The levels of serum tumor markers,immunoglobulin,cellular immune indexes and the incidence of adverse reactions were compared between the two groups.Result After treatment,the levels of matrix metalloproteinase 2(MMP2),matrix metalloproteinase 1(MMP1)and vascular endothelial growth factor(VEGF)in the two groups were lower than those before treatment,and the levels of MMP2,MMP1 and VEGF in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)in the two groups were lower than those before treatment,the levels of IgA,IgG and IgM in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of total T lymphocyte(TTL)in both groups were lower than those before treatment,while helper T lymphocyte(THL),suppressor T lymphocyte(TSL)and natural killer(NK)cell levels were higher than those before treatment,the levels of TTL,THL,TSL and NK cell in observation group were higher than those in control group,the differences were statistically signifi-cant(P<0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Surgery combined with chemotherapy can improve immune function and inhibit tumor invasion and metastasis in children with neuroblastoma.
作者
苏静
樊硕
李盼盼
SU Jing;FAN Shuo;LI Panpan(Pediatric Intensive Care Ward,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China)
出处
《癌症进展》
2024年第9期1037-1040,共4页
Oncology Progress
基金
河南省医学科技攻关计划联合共建项目(LHGJ20200338)。
关键词
神经母细胞瘤
免疫功能
化疗
手术
neuroblastoma
immune function
chemotherapy
surgery
