摘要
目的:探讨结直肠癌(CRC)组织中基质金属蛋白酶7(MMP7)的表达与微血管密度(MVD)的关系。方法:选取CRC组织140例为实验组,同期CRC旁组织30例作为对照组,实验组再根据MMP7表达分为阳性组(n=114)和阴性组(n=26)。应用免疫组织化学法检测实验组与对照组中MMP7表达和MVD值,分析MMP7的表达、MVD值与CRC患者临床病理特征的关系并分析二者的相关性。结果:实验组中MMP7阳性率与MVD均值分别为81.4%与(30.09±7.54);对照组中MMP7阳性率与MVD均值分别为36.7%与(15.80±4.57),实验组MMP7阳性率及MVD均值高于对照组(P<0.05)。MMP7阳性组MVD均值高于MMP7阴性组[(31.51±6.92)vs.(23.88±7.12),P<0.05]。多因素分析显示,MMP7阳性率及MVD值均与肿瘤最大径及淋巴结转移有关(P<0.05)。CRC组织中MMP7表达水平与MVD值正相关(P<0.05)。结论:CRC中MMP7呈高表达,并与MVD值正相关,提示MMP7可能促进CRC组织新生血管的形成,有望为CRC患者抗血管治疗提供新的理论依据。
Objective:To explore the correlation between the expression of matrix metalloproteinase 7(MMP7)and microvascular density(MVD)in colorectal cancer(CRC)tissues.Methods:140 cases of colorectal adenocarcinoma tissues were collected as the experimental group,and 30 cases of colorectal cancer adjacent tissues were collected as the control group.The experimental group was further divided into MMP7 positive group(n=114)and MMP7 negative group(n=26)based on MMP7 expression.Immunohistochemistry(IHC)was used to detect the expression and MVD value in the experimental group and the control group.The relationship between MMP7 expression,MVD value,and clinical pathological characteristics of CRC patients was analyzed and the correlation between them was analyzed.Results:The positive rate of MMP7 and the mean MVD in experimental group were 81.4%and 30.09±7.54,respectively.The positive rate of MMP7 and the mean value of MVD in control group were 36.7%and 15.80±4.57,respectively.The positive rate of MMP7 and the mean value of MVD in the former were higher than those in the latter,and the difference was statistically significant(P<0.05).The mean MVD of MMP7 positive patients was higher than that of MMP7 negative patients(31.51±6.92 vs.23.88±7.12,P<0.05).Multivariate analysis showed that the positive rate of MMP7 and MVD value were correlated with the maximum diameter of tumor and lymph node metastasis(P<0.05).The expression of MMP7 in CRC tissues was positively correlated with MVD values(P<0.05).Conclusion:MMP7 is highly expressed in CRC,and the expression of MMP7 is positively correlated with MVD value,suggesting that MMP7 may promote the formation of neovascularization in CRC tissue,which is expected to provide a new theoretical basis for the anti vascular treatment of CRC patients.
作者
黄一凡
白卓
何琳莉
HUANG Yi-fan;BAI Zhuo;HE Lin-li(Pathology Teaching and Research Office of Basic Medicine and Forensic Medicine,North Sichuan Medical College,Nanchong 637000;Department of Pathology,Meishan People s Hospital,Meishan 620000,Sichuan,China)
出处
《川北医学院学报》
CAS
2024年第6期732-736,共5页
Journal of North Sichuan Medical College
基金
四川省南充市市校科技战略合作项目(22SXQT0197)
四川省南充市哲学社会科学重点研究基地名老中医医案研究中心2023年度资助项目(YAZX23-ZD-01)。
