摘要
目的观察耳穴埋豆联合定眩颗粒治疗周围性眩晕的临床疗效及安全性。方法选取88例周围性眩晕患者,使用计算机随机法随机分为对照组与治疗组各44例,两组患者均给予止晕止吐、改善循环等西医常规治疗,对照组加用定眩颗粒口服,治疗组在对照组基础上配合耳穴埋豆辨证治疗,观察两组临床疗效、治疗前后眩晕障碍量表(DHI)和日常生活活动能力量表(ADL)评分、基底动脉的平均血流速度(VM)和血管阻力指数(RI)、血一氧化氮(NO)、神经肽Y(NPY)、血管内皮素1(ET-1)以及两组不良反应发生情况和复发率。结果治疗后,治疗组总有效率高于对照组(P<0.05);治疗组DHI评分较对照组下降明显(P<0.05),治疗组ADL评分较对照组回升明显(P<0.05);治疗组基底动脉VM较对照组增快明显(P<0.05),治疗组基底动脉RI降低较对照组明显(P<0.05);两组NPY水平与治疗前比较,无明显差异(P>0.05),治疗组NO水平较对照组升高更明显(P<0.05);治疗组ET-1水平较对照组下降更明显(P<0.05);治疗期间,均无不良反应发生,随访半年内复发率比较,差异无统计学意义(P>0.05)。结论耳穴埋豆联合定眩颗粒治疗周围性眩晕疗效显著,可调节NO和ET-1水平,提高基底动脉平均血流速度,降低血管阻力指数,改善临床症状,安全性高。
Objective:To observe the clinical efficacy and safety of auricular seed embedding combined with Dingxuan Granules in treating peripheral vertigo.Methods:88 patients with peripheral vertigo were randomly divided into a control group and a treatment group(44 cases each)using computer-generated randomization.Both groups received routine western medical treatments for anti-dizziness,anti-emetic,and circulation improvement.The control group was further administered Dingxuan Granules orally,while the treatment group,in addition to the control regimen,received auricular seed embedding based on syndrome differentiation.Clinical efficacy,DHI and ADL scores before and after treatment,mean blood flow velocity(VM)and resistivity index(RI)of the basilar artery,serum levels of nitric oxide(NO),neuropeptide Y(NPY),and endothelin-1(ET-1),adverse reactions,and recurrence rates were observed in both groups.Results:After treatment,the total effective rate in the treatment group was significantly higher than in the control group(P<0.05).The treatment group showed more decrease in DHI scores(P<0.05)and more increase in ADL scores(P<0.05)compared with the control group.The VM of the basilar artery was significantly faster in the treatment group(P<0.05),and the RI was significantly lower(P<0.05)than in the control group.No significant differences were found in NPY levels between the two groups before and after treatment(P>0.05),but the NO level was significantly higher in the treatment group(P<0.05).ET-1 levels decreased more significantly in the treatment group(P<0.05).Neither group reported adverse reactions during treatment,and there was no significant difference in recurrence rates within the first half-year follow-up(P>0.05).Conclusion:Auricular seed embedding combined with Dingxuan Granules shows significant eficacy in treating peripheral vertigo,which can regulate NO and ET-1 levels,increase the mean blood flow velocity of the basilar artery,reduce the resistivity index,improve clinical symptoms,and display high safety,thus it i
作者
黄昊
王兆民
程小娟
胡高文
魏伟
熊振开
胡志刚
孙军
谢强龙
张荣珍
Huang Hao;Wang Zhaomin;Cheng Xiaojuan;Hu Gaowen;Wei Wei;Xiong Zhenkai;Hu Zhigang;Sun Jun;Xie Qianglong;Zhang Rongzhen(Wuhu Traditional Chinese Medicine Hospital,Anhui,Wuhu 241000,China)
出处
《中国中医急症》
2024年第6期1055-1058,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
安徽省重点研究与开发计划项目(2022e07020067)。
关键词
周围性眩晕
耳穴埋豆
定眩颗粒
Peripheral vertigo
Auricular seed Embedding
Dingxuan Granules
