摘要
流感病毒可引起季节性流感及流感大流行,严重危害人类健康。抗流感病毒药物在控制流感爆发及流行中发挥重要作用。然而,当前可使用的抗流感病毒药物种类过少,且流感病毒极易突变,耐药病毒株不断增长,因此开发可抑制耐药病毒株的新药,以及开发具有全新抗病毒机制的抗流感病毒药物十分必要。通过对靶向流感病毒成分的抗流感病毒药物的研究进展进行综述,重点介绍各靶点药物的种类、作用机制、耐药产生情况以及如何针对耐药靶点进行“老药改造”和新靶点药物的开发,同时也对抗流感病毒药物的未来发展进行讨论,以期为流感病毒感染的治疗及药物研发提供参考。
Influenza viruses cause seasonal influenza and influenza pandemics,which pose a serious threat to human health.Antiinfluenza virus drugs are crucial in controlling the outbreak and spread of influenza.However,there are currently limited options of antiinfluenza virus drugs in clinical practice.Additionally,influenza viruses are highly prone to mutation,leading to an increase in drugresistant virus strains.Therefore,it is necessary to develop new drugs that can inhibit drug-resistant strains of the virus with novel antiviral mechanisms.This paper summarizes the research progress of anti-influenza virus drugs that target influenza virus components.It focuses on the types of drugs,their mechanisms of action,the occurrence of drug resistance,the transformation of old drugs and the development of new target drugs for drug resistance targets,as well as the future development of anti-influenza virus drugs,with the aim of providing some reference for therapy and the research and development of drugs against influenza virus infections.
作者
黎敏科
杨博尧
吴益喜
徐畅
梁欢欢
LI Minke;YANG Boyao;WU Yixi;XU Chang;LIANG Huanhuan(School of Pharmaceutical Sciences(Shenzhen),Sun Yat-sen University,Shenzhen 518107,China)
出处
《药学进展》
CAS
2024年第5期350-362,共13页
Progress in Pharmaceutical Sciences
关键词
流感病毒
抗病毒药物
耐药病毒株
新靶点
influenza virus
antiviral drug
drug-resistant virus strain
new target
