摘要
黄芪Astragali Radix是临床上常用的补气药,具有抗炎、抗肿瘤及免疫调节等药理作用。研究表明,黄芪活性成分对结肠癌发生、发展具有预防和显著治疗作用。黄芪活性成分能够抑制结肠癌早期炎症的发生发展,抑制结肠癌细胞增殖、抑制侵袭及转移、诱导凋亡及增强免疫调节能力等发挥抗结肠癌的作用,还可通过调控相关信号通路达到防治结肠癌的作用。通过对黄芪活性成分抗结肠癌的分子机制进行综述,为促进黄芪资源的开发利用和结肠癌的新药研发提供参考。
Huangqi(Astragali Radix)is a commonly used qi-tonifying drug in clinical practice,which has anti-inflammatory,antitumor and immunomodulatory pharmacological effects.Studies have shown that Astragali Radix active ingredients have preventive and significant therapeutic effects on the occurrence and development of colon cancer.Astragali Radix active ingredients can inhibit the occurrence and development of early inflammation of colon cancer,inhibit the proliferation of colon cancer cells,inhibit invasion and metastasis,induce apoptosis and enhance the ability of immune regulation to play an anti-colon cancer role,and can also regulate the relevant signaling pathways to prevent and treat colon cancer.The molecular mechanism of Astragali Radix active ingredients against colon cancer was reviewed to provide reference for the development and utilization of Astragali Radix resources and the development of new drugs for colon cancer.
作者
李付平
靳子明
刘成松
杨锡仓
张作潭
LI Fuping;JIN Ziming;LIU Chengsong;YANG Xicang;ZHANG Zuotan(Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China;Yang Xicang Famous Old Chinese Medicine Expert Studio,Lanzhou 730000,China)
出处
《中草药》
CAS
CSCD
北大核心
2024年第10期3549-3557,共9页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(82360944)
甘肃省中药炮制技术传承基地项目(甘卫中医函[2022]288号)
甘肃省科技计划资助项目(18JR2FA001)
兰州市城关区科技计划项目(2021-02-09)。
关键词
黄芪甲苷
黄芪多糖
芒柄花素
芒柄花苷
毛蕊异黄酮
结肠癌
细胞增殖
细胞凋亡
astragaloside
astragalus polysaccharide
formononetin
ononin
calycosin
colon cancer
cell proliferation
c ell apoptosis
