摘要
脑卒中是成人因病致残的主要病因。随着脑卒中诊疗技术的进步,卒中患者的死亡率大幅下降,然而其发病率不断增加,脑卒中幸存患者发展为慢性神经功能障碍越来越多。目前临床并没有明确促进脑卒中后功能修复的药物。多项研究表明,肠道菌群通过调控神经活性分子和免疫细胞功能可增强神经网络可塑性和减轻神经炎症,进而改善脑卒中患者预后。本文通过综述既往相关研究,阐述脑卒中后肠道菌群对神经网络可塑性和神经炎症的作用机制以及对脑卒中后功能恢复的影响,探究其改善脑卒中后神经功能障碍的临床价值和可行性。
Stroke is the main cause of disability in adults.With the progress of stroke diagnosis and treatment technology,the mortality rate of stroke patients has decreased significantly,but its incidence keeps increasing,and there is an increasing number of stroke survivors develop chronic neurological disorders.At present,there is no clear drug to promote functional repair after stroke.Several studies have shown that gut microbiota can improve stroke prognosis by regulating neuroactive molecules and immune cell functions,enhancing neural network plasticity,and reducing neuroinflammation.Based on a review of previous studies,this paper describes the mechanism of action of gut microbiota on neural network plasticity and neuroinflammation after stroke and its impact on functional recovery after stroke and explores its clinical value and feasibility in improving neurological dysfunction after stroke.
作者
李颖
王一芳
林瑜辉
吴晋
LI Ying;WANG Yifang;LIN Yuhui(Department of Neurology,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 21001l,China)
出处
《临床神经病学杂志》
CAS
2024年第2期149-152,共4页
Journal of Clinical Neurology
基金
江苏省自然科学基金(BK20191500)。
