摘要
目的观察低温等离子消融高选择性翼管神经分支阻断术治疗中重度变应性鼻炎(AR)的效果。方法选取2020年3月至2022年3月在该院就诊的96例中重度AR患者,按治疗方法不同分为研究组与对照组,每组48例。研究组行低温等离子消融高选择性翼管神经分支阻断术治疗,对照组行常规药物治疗。观察两组治疗后12个月疗效、生活质量、不良反应,比较治疗前及治疗后3个月两组主观症状评分、鼻阻力、鼻声反射指标及血清指标[骨桥蛋白(OPN)、单核细胞趋化蛋白-1(MCP-1)、免疫球蛋白E(IgE)、白细胞介素-5(IL-5)]水平。结果研究组治疗总有效率为95.83%,高于对照组的81.25%(P<0.05)。两组治疗后鼻塞、鼻痒、打喷嚏、流清涕、眼部症状、肺部症状评分均低于治疗前(P<0.05),且治疗后研究组鼻塞、鼻痒、打喷嚏、流清涕、眼部症状、肺部症状评分均低于对照组(P<0.05)。与治疗前相比,两组治疗后鼻阻力降低(P<0.05),鼻腔容积、最小横截面积增大(P<0.05);且治疗后研究组鼻阻力低于对照组(P<0.05),鼻腔容积、最小横截面积均大于对照组(P<0.05)。与治疗前相比,治疗后两组血清OPN、MCP-1、IgE、IL-5水平均降低(P<0.05);且治疗后研究组血清OPN、MCP-1、IgE、IL-5水平均低于对照组(P<0.05)。两组治疗前非鼻/眼症状、睡眠、情感、眼症状、行为、鼻症状、日常生活评分比较,差异均无统计学意义(P>0.05);治疗后研究组非鼻/眼症状、睡眠、眼症状、鼻症状评分均低于对照组(P<0.05)。研究组患者术后不良反应总发生率为4.17%,高于对照组的2.08%,但差异无统计学意义(P>0.05)。结论对中重度AR患者进行低温等离子消融高选择性翼管神经分支阻断术治疗疗效确切,可明显改善患者症状,提升其生活质量。
Objective To observe the therapeutic effect of low temperatur e plasma ablation highly selective pterygium nerve branch occlusion in the treatment of moderate to severe allergic rhinitis(AR).Methods Ninety-six patients with moderate to severe AR visited in this hospital from March 2020 to March 2022 were selected and divided into the study group and control group according to different treatment methods,48 cases in each group.The study group underwent low temperature plasma ablation highly selective pterygium nerve branch occlusion,while the control group conducted the conventional medication.The efficacy,quality of life and adverse reactions after 12-month-treatment in the two groups were observed,and the subjective symptom scores,nasal resistance,nasal acoustic reflex indicators and serum indicators[osteopontin(OPN),monocyte chemotactic protein-1(MCP-1),immunoglobulin E(IgE),and interleukin-5(IL-5)]levels were compared between before treatment and after 3-month treatment.Results The total effective rate in the study group was 95.83%,which was higher than 81.25%in the control group(P<0.05).The scores of nasal congestion,nasal itching,sneezing,runny nose,eye symptoms and lung symptoms after treatment in the two groups were lower than those before treatment(P<0.05),moreover the scores of nasal congestion,nasal itching,sneezing,runny nose,eye symptoms and lung symptoms in the study group were lower than those in the control group(P<0.05).Compared with before treatment,the nasal resistance after treatment in the two groups was decreased(P<0.05)and the nasal volume and minimum cross-sectional area were increased(P<0.05);moreover the nasal resistance after treatment in the study group was lower than that in the control group(P<0.05),while the nasal volume and minimum cross-sectional area were higher than those in the control group(P<0.05).Compared with before treatment,the serum OPN,MCP-1,IgE and IL-5 levels after treatment in both groups were decreased(P<0.05);moreover the serum OPN,MCP-1,IgE and IL-5 levels after tr
作者
郑鹏
文波
朱冰
陈珍
ZHENG Peng;WEN Bo;ZHU Bing;CHEN Zhen(Department of Otolaryngology Head and Neck Surgery,Mianyang Wanjiang Ophthalmology Hospital,Mianyang,Sichuan 621000,China)
出处
《检验医学与临床》
CAS
2024年第12期1709-1713,1720,共6页
Laboratory Medicine and Clinic
基金
四川省绵阳市卫生健康委员会2022年科研课题鼓励项目(202268)。
