摘要
目的:探究荜铃胃痛颗粒联合西药三联或四联的中西医结合疗法与传统西药疗法根除幽门螺杆菌(H.pylori)的有效性及安全性。方法:检索PubMed、Embase、Cochrane Library、中国知网、万方数据库、中国生物医学文献服务系统,收集有关荜铃胃痛颗粒应用于H.pylori根除治疗的随机对照研究,检索年限均为数据库建库至2022年11月,根据Cochrane系统评价方法对检索到的文献进行数据提取以及文献质量评估。采用RevMan 5.4软件进行Meta分析。结果:共纳入4篇文献,506例患者。Meta分析结果显示,在H.pylori根除率方面,试验组高于对照组(OR=4.18,95%CI:2.57~6.79,I 2=0%,P<0.00001)。在安全性方面,试验组不良反应发生率低于对照组(OR=0.30,95%CI:0.10~0.85,I 2=0%,P=0.02)。结论:含荜铃胃痛颗粒的中西医整合治疗方案在疗效与安全性方面均明显优于西药四联、三联疗法。
Objective:To investigate the efficacy and safety of the integrated traditional Chinese and Western medicine therapy with Biling Weitong Granules in combination with conventional Western medicine quadruple or triple therapy compared to traditional Western medicine therapy for eradicating Helicobacter pylori(H.pylori).Methods:PubMed,Embase,Cochrane Library,China National Knowledge Infrastructure,Wanfang Database and Sinomed were searched,and the randomized controlled studies about the application of Biling Weitong Granule for eradicating H.pylori eradication were collected.The retrieval period was from the establishment of the database to November 2022.Data extraction and literature quality evaluation were performed on the retrieved literature according to the Cochrane system evaluation method.Meta-analysis was performed using RevMan 5.4 software.Results:A total of 4 articles and 506 patients were included.The results of Meta-analysis showed that the eradication rate of H.pylori in the experimental group was higher than that in the control group(OR=4.18,95%CI:2.57-6.79,I 2=0%,P<0.00001).In terms of safety,the incidence of adverse reactions in the experimental group was lower than that in the control group(OR=0.30,95%CI:0.10-0.85,I 2=0%,P=0.02).Conclusion:The integrated traditional and Western medicine treatment regimen with Biling Weitong Granules is significantly better than the western medicine quadruple and triple therapy in terms of efficacy and safety.
作者
孟旨毅
孟宪梅
刘飞飞
张静洁
年媛媛
王驰
MENG Zhiyi;MENG Xianmei;LIU Feifei;ZHANG Jingjie;NIAN Yuanyuan;WANG Chi(Department of Gastroenterology,the Second Affiliated Hospital of Baotou Medical College,Baotou 014030,China)
出处
《包头医学院学报》
CAS
2024年第6期56-60,共5页
Journal of Baotou Medical College
关键词
幽门螺杆菌
荜铃胃痛颗粒
中西医结合
根除治疗
Helicobacter pylori
Biling Weitong Granules
Integrated traditional Chinese and western medicine
Eradicate treatment
