摘要
目的探究直肠癌患者围手术期输血不良反应的发生情况,分析发生不良反应的影响因素。方法选取2018年1月至2022年6月在文昌市人民医院和中南大学湘雅医学院附属海口医院接受围手术期输血治疗并出现输血不良反应的54例直肠癌患者为观察组,另选取同期未出现输血不良反应的60例直肠癌患者为对照组。收集2组患者基础资料和临床资料,建立Logistic回归模型,分析直肠癌围手术期输血不良反应的影响因素。结果观察组患者的不良反应主要以发热、过敏为主,未见发热且过敏反应,未发生溶血反应。观察组患者的输血次数、输注血液成分、基础疾病、过敏史、发血-输血间隔时间与不良反应类型无明显关系(P>0.05),有输血史患者出现过敏反应占比高于发热反应(P<0.05)。观察组患者的输血史、过敏史、输血次数>2次、发血-输血间隔时间≥0.5 h占比高于对照组(P<0.05)。Logistic回归模型结果显示,有输血史、过敏史和输血次数>2次均为输血不良反应的危险因素,发血-输血间隔时间<0.5 h为保护因素(P<0.05)。结论输血治疗前,需要加强对直肠癌患者各项临床资料的分析,对有输血史、过敏史和输血次数较多的患者给予重点关注,根据患者实际需求选择血液制品,并尽量缩短发血-输血间隔时间,以此减少输血不良反应。
Objective To investigate the occurrence and influencing factors of adverse reactions of perioperative blood transfusion in patients with rectal cancer.Methods Fifty-four patients with rectal cancer who received perioperative blood transfusion and experienced adverse reactions to blood transfusion in Wenchang People’sHospital and Haikou Affiliated Hospital of Central South University Xiangya School of Medicine from January 2018 to June 2022 were selected as the observation group.Sixty patients with rectal cancer who did not have adverse reactions to blood transfusion during the same period were assigned to the control group.The basic and clinical data of the two groups were collected.Logistic regression model was established to analyze the influencing factors of perioperative adverse reactions of blood transfusion in patients with rectal cancer.Results The main adverse reactions in the observation group were fever and allergy.The patient with fever and allergic reaction was not found,and no hemolytic reaction occurred.There were no significant differences in the types of adverse reactions caused by the number of transfusions,composition of transfused blood,underlying diseases,allergic history,or the interval between blood transfusion and transfusion among patients in the observation group(all P>0.05).The incidence of allergic reactions was higher than that of fever reaction in patients with history of blood transfusion(P<0.05).The proportions of patients with blood transfusion history,allergy history,number of transfusion>2 times and interval between blood transfusion and transfusion≥0.5 h in the observation group were significantly higher than those in the control group(all P<0.05).The results of Logistics regression model showed that history of blood transfusion,history of allergy and transfusion times>2 were risk factors for adverse reactions of blood transfusion,and the interval between blood transfusion and transfusion<0.5 h was a protective factor(P<0.05).Conclusion Before blood transfusion treatment,it
作者
林书彪
云小健
符兴胜
符方崇
Lin Shubiao;Yun Xiaojian;Fu Xingsheng;Fu Fangchong(Department of Blood Transfusion,Wenchang People’s Hospital,Wenchang 571300,China)
出处
《海军医学杂志》
2024年第5期516-520,共5页
Journal of Navy Medicine
基金
海南省重点研发计划(ZDYF2019186)。
关键词
直肠癌
输血
不良反应
影响因素
Rectal cancer
Blood transfusion
Adverse reactions
Influencing factors
