摘要
目的:探讨肠内外营养支持对结直肠癌化疗患者营养状况、免疫状况及不良反应的影响。方法:收集2018年2月—2021年3月在我院就诊的200例结直肠癌患者为研究对象,随机均分至观察组和对照组各100例,2组患者一般情况具有可比性(P>0.05)。在化疗的基础上,2组患者均接受膳食指导,对照组患者经口摄入能量不足部分采用经肠外营养补充,观察组患者则采用肠内联合肠外的方法补充。比较2组患者营养状况、免疫状况和不良反应发生率的差异。结果:化疗后,观察组患者血清TP、PA、ALB水平改善情况较对照组明显(P<0.05);观察组患者血清IgG、IgM、IgA升高水平也较对照组显著(P<0.05);观察组患者总不良反应发生率低于对照组(χ^(2)=4.861,P=0.027),白细胞下降、消化道反应、肝功能损伤及骨髓抑制发生例数均低于对照组。结论:在结直肠癌患者化疗期间,给予适当的肠内及肠外营养支持,可有效改善患者营养状况和免疫状况,降低不良反应发生率。
【Objective】 To explore the effect of enteral and parenteral nutrition support on the nutritional status, immune status and adverse reactions of patients with colorectal cancer during chemotherapy.【Method】A total of 200 colorectal cancer patients who were treated in our hospital from February 2018 to March 2021 were collected as the research objects, and they were randomly divided into the observation group and the control group with 100 cases each. The general conditions of the two group patients are comparable(P>0. 05). On the basis of chemotherapy, both group patients received dietary guidance. The control group received parenteral nutrition supplementation for the insufficient oral energy intake, and the observation group received parenteral nutrition combined with parenteral nutrition. The differences in nutritional status, immune status and incidence of adverse reactions between the two group patients were compared.【Result】After chemotherapy, the improvement of serum TP, PA and ALB levels in the observation group was more significant than that in the control group(P<0. 05). The elevated levels of serum IgG, IgM and IgA in the observation group were also significantly higher than those in the control group(P<0. 05). The incidence of total adverse reactions in the observation group was lower than that in the control group (χ^(2)= 4. 861,P=0. 027). The incidence of leukopenia, gastrointestinal reactions, liver damage and bone marrow suppression were all lower than those in the control group.【Conclusion】During chemotherapy for patients with colorectal cancer, proper enteral and parenteral nutritional support can effectively improve the nutritional status and immune status, and reduce the incidence of adverse reactions.
作者
袁伟
陈文锋
杨小娟
王佳丽
王海
王静霞
YUAN Wei;CHEN Wen-feng;YANG Xiao-juan;WANG Jia-li;WANG Hai;WANG Jing-xia(Clinical Nutrition,Zhabei Central Hospital,Jing'an District of Shanghai City,Shanghai 200070,China;Department of Academy of Physics,Zhabei Central Hospital,Jing'an District of Shanghai City,Shanghai 200070,China)
出处
《中国食物与营养》
2022年第1期67-70,共4页
Food and Nutrition in China
基金
上海市静安区卫生科研课题(项目编号:2020YL01)。
关键词
结直肠癌
肠内营养
肠外营养
营养状况
不良反应
colorectal cancer
enteral nutrition
parenteral nutrition
nutritional status
adverse reaction
