摘要
目的系统评价桃红四物汤(TSD)治疗糖尿病周围神经病变(DPN)的安全性和有效性,为中医药干预DPN提供依据。方法系统检索PubMed数据库,EMbase数据库、Cochrane Library数据库、中国知网、维普数据库、万方数据知识服务平台,搜集以桃红四物汤治疗糖尿病周围神经病变的研究文献,检索时间均从建库至2023年12月,由2名研究人员进行文献筛选、质量评价和提取有效数据,用Revman5.4软件进行Meta分析。对比单用/联用桃红四物汤(试验组)与常规西药(对照组)临床有效率、正中神经传导速度、腓总神经传导速度、中医证候积分、TCSS评分和糖化血红蛋白水平(HbA 1c)以及不良反应等指标。结果最终纳入13项随机对照试验(RCTs)1159例研究对象。Meta分结果显示,试验组临床有效率高于对照组[RR(95%CI)=1.20(1.14,1.27),P<0.001],试验组降低中医证候积分的效果优于对照组[MD(95%CI)=-3.68(-4.64,-2.72),P<0.001],试验组降低TCSS积分的效果优于对照组[MD(95%CI)=-1.77(-2.43,-1.10),P<0.001],试验组提高正中神经传导速度的效果优于对照组[MD(95%CI)=4.07(1.98,6.15),P<0.001],试验组提高腓总神经传导速度的效果优于对照组[MD(95%CI)=4.81(3.00,6.61),P<0.001],试验组降低糖化血红蛋白水平的效果优于对照组,但差异无统计学意义[MD(95%CI)=-0.04(-0.28,0.19),P=0.72]。结论桃红四物汤可用于治疗糖尿病周围神经病变,联用西药则效果显著,均优于单用西药治疗。
Objective To systematically evaluate the safety and effectiveness of Taohong Siwu Decoction(TSD)in the treatment of diabetes peripheral neuropathy(DPN),so as to provide a basis for Chinese medicine intervention in DPN.Methods The PubMed database,Embase database,Cochrane Library database,CNKI,VIP,Wanfang data knowledge service platform were systematically searched,and the research literature on the treatment of diabetes peripheral neuropathy with Taohong Siwu Decoction was collected.The search time was from the establishment of the database to December 2023.Two researchers screened the literature,evaluated the quality,and extracted effective data.The Meta-analysis was conducted with Revman 5.4 software.Compare the clinical efficacy,median nerve conduction velocity,common peroneal nerve conduction velocity,traditional Chinese medicine syndrome score,TCSS score,glycated hemoglobin level(HbA 1c),and adverse reactions between single/combined use of Taohong Siwu Decoction(experimental group)and conventional Western medicine(control group).Result The final inclusion of 13 RCTs included 1159 study subjects.The Meta-analysis showed that the experimental group had a better effect on improving clinical efficacy than the control group[RR(95%CI)=1.20(1.14,1.27),P<0.001],the experimental group had a better effect on reducing traditional Chinese medicine syndrome scores than the control group[MD(95%CI)=-3.68(-4.64,-2.72),P<0.001],the experimental group had a better effect on reducing TCSS scores than the control group[MD(95%CI)=-1.77,(-2.43,-1.10),P<0.001],and the experimental group had a better effect on improving median nerve conduction velocity than the control group[MD(95%CI)=4.07(1.98,6.15),P<0.001].The experimental group showed a better effect on improving the conduction velocity of the common peroneal nerve than the control group,but there bad no significant statistical difference[MD(95%CI)=4.81(3.00,6.61),P<0.001],the experimental group showed a better effect in reducing glycated hemoglobin levels than the control group
作者
吴晴
吕溪涓
胡可心
李瑜璠
王梦凡
方朝晖
Wu Qing;Lyu Xijuan;Hu Kexin;Li Yufan;Wang Mengfan;Fang Zhaohui(Anhui University of Traditional Chinese Medicine,Anhui Province,Hefei 230038,China)
出处
《疑难病杂志》
CAS
2024年第6期736-742,750,共8页
Chinese Journal of Difficult and Complicated Cases
基金
国家自然科学基金资助项目(82174153,81774286)
国家重点研发计划“战略性国际科技创新合作”重点专项(2020YFE0201800)
2型糖尿病中医药循证能力提升项目(2023-24)
安徽省中医药领军人才及培养对象项目(20190027)。
