摘要
为了揭示视黄醇结合蛋白(RBP4)在肝细胞癌(LIHC)中的功能作用,对RBP4的结构及理化性质进行了分析。基于公共数据库明确了RBP4在正常组织和LIHC中的表达,分析了其与LIHC患者的病理状态与临床生存预后的关系。结果显示:RBP4的等电点(pI)为5.76,其β-桶核心是视黄醇的结合中心,亲水性强,具有一个信号肽;RBP4在正常肝组织中的表达高于LIHC,并且高表达RBP4有更好的预后生存率(log rank P<0.001);RBP4的表达可能会缓解LIHC的进展,也可作为潜在生物标志物应用于LIHC的临床诊断与预后中。
To investigate the function of retinol-binding protein 4(RBP4)in liver hepatocellular carcinoma(LIHC).The study firstly analyzed the structure and physicochemical properties of RBP4.Secondly,RBP4 expression profile was compared between normal tissue and LIHC based on the database.And then,the relationship between RBP4 expression levels and clinical survival prognosis of LIHC patients was shown.The results show that RBP4 has an isoelectric point(pI)of 5.76,and its β-barrel core is the binding center of retinol,which is highly hydrophilic and has a signal peptide.The expression of RBP4 is higher in normal liver tissues than in LIHC,and the higher expression of RBP4 has better prognostic survival(log rank P<0.001).The expression of RBP4 may alleviate the progression of LIHC and may also be used as one of the potential biomarkers for clinical diagnosis and prognosis of LIHC.
作者
聂赛娅
汪一川
郝旭
董启启
程佳
NIE Saiya;WANG Yichuan;HAO Xu;DONG Qiqi;CHENG Jia(School of Biological Science and Engineering,Shaanxi University of Technology,Hanzhong 723000,China;Engineering Research Center of quality improvement and safety control of Qinba special meat products,Shaanxi University of Technology,Hanzhong 723000,China;Qinba State Key Laboratory of Biological Resources and Ecological Environment(Incubation),Shaanxi University of Technology,Hanzhong 723000,China)
出处
《陕西理工大学学报（自然科学版）》
2024年第3期70-76,共7页
Journal of Shaanxi University of Technology:Natural Science Edition
基金
秦巴生物资源与生态环境省部共建重点实验室(培育)“市校共建”科研专项项目(SXC-2101)。
关键词
视黄醇结合蛋白
生物信息学
肝细胞癌
retinol-binding protein 4
bioinformatics
liver hepatocellular carcinoma
