摘要
目的探讨性激素水平与人乳头瘤病毒(HPV)感染情况在评估患者阴道微生态变化中的交互作用,为阴道微生态失调的诊断和治疗提供依据。方法选取2020年2月至2023年2月在合肥市第二人民医院确诊的49例HPV感染女性患者作为患者组,选取同期于同一医院检查的49例HPV阴性女性作为对照组。检测两组的性激素水平(雌二醇、孕酮、睾酮、卵泡刺激素、黄体生成素)和阴道微生态(乳酸杆菌、厌氧菌、芽孢杆菌、链球菌、大肠杆菌、念珠菌)的变化,分析性激素水平与HPV感染的相关性,以及微生态变化与性激素水平和HPV感染的关系。结果患者组性激素水平与对照组相比均有显著差异(P<0.05),其中雌二醇、孕酮、睾酮水平均降低,而卵泡刺激素、黄体生成素水平均升高。患者组阴道微生态与对照组相比也有显著差异(P<0.05),其中乳酸杆菌水平显著降低,而厌氧菌、芽孢杆菌、链球菌、大肠杆菌、念珠菌水平均显著升高。性激素水平与HPV感染呈负相关(r=-0.56,P<0.01),阴道微生态与性激素水平和HPV感染呈正相关(r=0.63,P<0.01)。结论性激素水平与HPV感染在评估患者阴道微生态变化中有交互作用,性激素水平降低和HPV感染增加均可导致阴道微生态失调,进而影响患者的生殖健康。
Objective To explore the interaction between sex hormone levels and human papilloma virus(HPV)infection in evaluating patients′vaginal microbiota changes,providing insights for the diagnosis and treatment of vaginal microbiota dysbiosis.Methods A total of 49 female patients diagnosed with HPV infection in Hefei Second People′s Hospital from February 2020 to February 2023 were selected as the patient group.Another 49 HPV-negative women undergoing examinations at the same hospital during the same period were selected as the control group.Levels of sex hormones(estradiol,progesterone,testosterone,follicle stimulating hormone,and luteinizing hormone)and changes in the vaginal microbiota(lactobacilli,anaerobes,bacillus,streptococci,E.coli,and Candida)were detected.The correlation between sex hormone levels and HPV infection and the relationship between changes in the vaginal microbiota and both sex hormone levels and HPV infection were analyzed.Results The levels of sex hormones in the patient group showed significant differences compared to the control group(P<0.05),with decreased levels of estradiol,progesterone,and testosterone,and increased levels of follicle stimulating hormone and luteinizing hormone.Significant differences were also found in the vaginal microbiota between the patient group and the control group(P<0.05),with a significant reduction in lactobacilli and increased levels of anaerobes,bacillus,streptococci,E.coli,and Candida.Sex hormone levels were negatively correlated with HPV infection(r=-0.56,P<0.01),while the vaginal microbiota showed a positive correlation with sex hormone levels and HPV infection(r=0.63,P<0.01).Conclusions Sex hormone levels and HPV infection interact to predict changes in the vaginal microbiota.Reduced sex hormone levels and HPV infection can lead to dysbiosis of the vaginal microbiota,thereby affecting reproductive health.
作者
曹珺
孙虹蕾
陈贞
CAO Jun;SUN Honglei;CHEN Zhen(Department of Laboratory,the Second People′s Hospital of Hefei(Hefei Hospital Affiliated to Anhui Medical University),Hefei 230011,Anhui,China)
出处
《中国性科学》
2024年第5期82-85,共4页
Chinese Journal of Human Sexuality
基金
2022年安徽省重点研究与开发计划项目(2022e07020028)。
关键词
性激素
人乳头瘤病毒感染
阴道微生态
交互作用
Sex hormones
Human papilloma virus infection
Vaginal microbiota
Interaction
