摘要
目的观察枝茯苓丸加味治疗慢性前列腺炎(Chronic prostatitis,CP)患者的疗效及对其炎症调控的作用机制。方法选取2022年1月—2023年1月期间河南省中医院收治的CP患者122例,采用电脑随机数字表法分为对照组和观察组,每组各61例。对照组给予常规西药治疗,观察组在对照组基础上给予桂枝茯苓丸加味治疗,疗程8周。观察比较治疗前后评价中医证候积分和慢性前列腺炎症状指数(NIH-CPSI),测量尿动力学参数[最大尿流率(Maximum urinary flow rate,Qmax)、平均尿流率(Average urinary flow rate,Qave)和残余尿量(Residual urine volume,RUV)],检测前列腺按摩液(Expressed prostatic secretious,EPS)中炎症因子[白介素-1β(Interleukin-1β,IL-1β)、白介素-6(Interleukin-6,IL-6)、肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)]水平,临床疗效、安全性及3个月后复发率。结果治疗后两组患者NIH-CPSI评分和中医证候积分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组NIH-CPSI评分和中医证候积分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者Qmax、Qave均较治疗前明显升高,RUV均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组Qmax、Qave明显高于对照组,RUV明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者IL-1β、IL-6和TNF-α水平均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组IL-1β、IL-6和TNF-α水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组临床控制率68.85%(42/61)、总有效率91.80(56/61)均明显高于对照组47.54%(29/61)、75.41%(46/61),差异有统计学意义(P<0.05)。治疗期间,两组患者均未出现明显不良反应,治疗前后检查肝肾功能、三大常规等均无明显异常变化。随访期间,观察组3例复发(7.14%),对照组7例复发(24.14%),观察组的短期复发率明显低于对照组,差异有统计学意义(χ^(2)=9.701,P=0.002)�
Objective To investigate the efficacy of modified Guizhi Fuling Pills in the treatment of patients with chronic prostatitis(CP)and its mechanism of inflammatory regulation.Methods A total of 122 patients with CP admitted to Henan Province Hospital of TCM from January 2022 to January 2023 were selected and randomly divided into a control group and an observation group by computer,with 61 patients in each group.The control group was treated with conventional Western medicine,while the observation group was treated with modified Guizhi Fuling Pills for eight weeks on the basis of the control group.The traditional Chinese medicine(TCM)syndrome score and CP symptom index(NIH-CPSI)were evaluated before and after treatment,and the urodynamic parameters[maximum urinary flow rate(Qmax),average urinary flow rate(Qave),and residual urine volume(RUV)] were measured.The levels of inflammatory factors[interleukin-1β(IL-1 β),interleukin-6(IL-6),and tumor necrosis factor α(TNF-α)] in expressed prostatic secretions(EPS)were detected.The clinical efficacy,safety,and recurrence rate after three months between the two groups were compared.Results After treatment,the TCM syndrome and NIH-CPSI scores in the two groups decreased,and the differences were statistically significant(P<0.05);compared with those in the control group,the NIH-CPSI and TCM scores in the observation group were lower(P<0.05).After treatment,the Qmax and Qave increased,and RUV decreased in the two groups(P<0.05);compared with the control group,the observation group showed a more significant increase in Qmax and Qave and a more significant decrease in RUV(P<0.05).After treatment,the levels of IL-1β,IL-6,and TNF-α in the two groups decreased(P<0.05);compared with those in the control group,the levels of IL-1β,IL-6,and TNF-α in the observation group were lower(P<0.05).After treatment,the clinical control rate and total effective rate of the observation group were 68.85%(42/61)and 91.80%(56/61),respectively,which were significantly higher than 47.54%(29/61)and
作者
贾鑫瑜
门波
井瑞源
林澍坤
郭闯豪
华众
李强
路奥迪
JIA Xin-yu;MEN Bo;JING Rui-yuan;LIN Shu-kun;GUO Chuang-hao;HUA Zhong;LI Qiang;LU Aodi(The Second School of Clinical Medicine,Henan University of Chinese Medicine,Zhengzhou Henan 450046;Department of Reproductive Medicine,Henan Province Hospital of TCM,Zhengzhou Henan 450002;College of Orthopedics and Traumatology,Henan University of Chinese Medicine,Zhengzhou Henan 450046)
出处
《世界中西医结合杂志》
2024年第5期957-962,共6页
World Journal of Integrated Traditional and Western Medicine
基金
河南省中医药科学研究专项课题(2023ZY2102)。
关键词
慢性前列腺炎
桂枝茯苓丸
复发
炎症
Chronic Prostatitis
Guizhi Fuling Pills
Recurrence
Inflammation
