摘要
背景:随着现代生活方式的改变及社会老龄化的加剧,慢性前列腺炎/慢性盆腔疼痛综合征(Chronic Prostatitis/Chronic Pelvic Pain Syndrome,CP/CPPS)的发病率逐年增高,目前多以西医治疗为主,存在一定的不良反应及并发症。艾灸治疗CP/CPPS有良好的疗效,但缺乏循证证据。目的:系统评价艾灸治疗CP/CPPS的疗效和安全性。方法:按照检索策略检索Cochrane临床对照试验中心注册库、Pubmed、Embase、中国生物医学文献系统数据库、中国知网、维普中文科技期刊数据库、万方数据库等相关数据库,检索时间均从建库到2022年4月1日。筛选出艾灸治疗CP/CPPS的随机对照试验(Randomized Controlled Trial,RCT)文献,主要结局指标:临床有效率、美国国立卫生研究院慢性前列腺炎症状指数(National Institutes of Health Chronic Prostatitis Index,NIH-CPSI)评分、疼痛数字评分法(Numerical Rating Scales,NRS)评分、生活质量评价量表(Quality of Life,QOL)评分、尿道分泌物(Urethral Discharge,UD)评分、白细胞计数(White Blood Cell Count,WBC)。根据Cochrane手册对纳入文献进行质量评价。运用Review Manager 5.4和Stata 16.0软件对数据进行分析。结果:纳入15篇文献,包括1 301例患者。试验组临床有效率[相对危险度(RR)=1.22,95%置信区间(CI)(1.16,1.30),P <0.000 01]高于对照组。试验组NIH-CPSI评分[均数差(MD)=1.55,95%CI(–2.15,5.25),P <0.000 1]、NRS评分[MD=–0.01,95%CI(–2.37,2.34),P <0.000 1]、QOL评分[MD=0.12,95%CI(–3.58,3.83),P=0.95]、UD评分[MD=–1.07,95%CI(–1.42,0.71),P <0.000 1], WBC[MD=2.79,95%CI(1.28,4.30),P <0.000 1]低于对照组。对临床有效率、NIH-CPSI评分进行亚组分析,临床有效率均高于对照组[RR=1.20,95%CI(1.13,1.28),P <0.000 01;RR=1.33,95%CI(1.56,1.53),P <0.000 1],NIH-CPSI评分均低于对照组[MD=0.47,95%CI(–1.46,2.39),P <0.000 1;MD=7.69,95%CI(–1.22,16.50),P <0.000 1]。结论:艾灸治疗CP/CPPS的疗效和安全性良好,但仍需更多高质
Background:The incidence of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)is increasing with the change of modern lifestyle and the aggravation of the aging society.At present,western medicine is mainly used for treatment,however,there are some adverse reactions and complications.Moxibustion on CP/CPPS has a good effect,but there is a lack of evidence-based evidence.Objective:To systematically evaluate the efficacy and safety of moxibustion in the treatment of CP/CPPS.Methods:According to the search strategy,Cochrane Clinical Controlled Trial Center Registry,Pubmed,Embase,China Biomedical Literature Database,CNKI,VIP Chinese Scientific and Technological Journal Database,Wanfang Database and other relevant databases were searched from the establishment of each database to April 1,2022.RCT literature on moxibustion in the treatment of CP/CPPS was screened,and the main outcome indicators were clinical effective rate,NIHI-CPSI score,NRS score,QOL score,UD score,WBC.The quality of the included literature was evaluated according to the Cochrane handbook.Review Manager 5.4 and Stata 16.0 were used to analyze the data.Results:Fifteen articles were included,including 1301 patients.The clinical effective rate in the test group[RR=1.22,95%CI(1.16,1.30),P<0.00001]was higher than the control group.NIH-CPSI score[MD=1.55,95%CI(–2.15,5.25),P<0.0001],NRS score[MD=–0.01,95%CI(–2.37,2.34),P<0.0001],QOL score[MD=0.12,95%CI(–3.58,3.83),P=0.95],NRS score[MD=–0.01,95%CI(–2.37,2.34),P=0.95],UD score[MD=–1.07,95%CI(–1.42,0.71),P<0.0001],WBC[MD=2.79,95%CI(1.28,4.30),P<0.0001]in the test group were lower than those in the control group.Subgroup analysis of clinical effective rate and NIH-CPSI score showed that the clinical effective rate was higher than that in the control group[RR=1.20,95%CI(1.13,1.28),P<0.00001;RR=1.33,95%CI(1.56,1.53),P<0.0001].The NIH-CPSI scores were lower than the control group[MD=0.47,95%CI(–1.46,2.39),P<0.0001;MD=7.69,95%CI(–1.22,16.50),P<0.0001].Conclusion:Moxibustion on CP/CPPS has
作者
黄文文
郭栋
姜璐
孙咪
谢珍聪
余洲
俞雅婷
王丹丹
HUANG Wenwen;GUO Dong;JIANG Lu;SUN Mi;XIE Zhencong;YU Zhou;YU Yating;WANG Dandan
出处
《中医临床研究》
2024年第6期21-28,共8页
Clinical Journal Of Chinese Medicine
基金
全国中医学术流派传承工作室第二轮建设项目(XSLP-2013-35)
济南市临床医学科技创新计划(202019154)。
