摘要
目的研究医院住院患者感染耐碳青霉烯肠杆菌(CRE)的预后危险因素。方法通过病原学标本分离鉴定和药敏试验方法,对某医院住院患者医院获得性CRE感染预后危险因素进行统计分析。结果共调查分析CRE感染患者135例,CRE主要分离自下呼吸道分泌物,构成比为57.04%。临床分离的CRE菌株对头孢类抗菌药物耐药率超过70%,对氨苄西林舒巴坦和妥布霉素耐药率达到50%~80%。多因素分析显示,血小板计数、胆红素水平、合并心脑血管疾病、多器官功能障碍综合征、胃管插管等因素构成CRE感染患者预后独立危险因素。结论该医院CRE感染部位主要为下呼吸道,影响患者预后的危险因素明确,应制订针对性的防控措施。
Objective To investigate the prognostic factors of carbapenem resistant Enterobacteriaceae(CRE)infection in hospitalized patients.Methods Through pathogen specimen isolation and identification and antimicrobial susceptibility testing,the prognostic risk factors of hospital acquired CRE infection among hospitalized patients in a hospital were statistically analyzed.Results A total of 135 patients with CRE infection were investigated and analyzed.CRE was mainly isolated from lower respiratory tract secretions,accounting for 57.04%.The resistance rate of clinically isolated CRE strains to cephalosporin antibiotics exceeded 70%,and the resistance rate to ampicillin sulbactam and tobramycin reached 50%to 80%.Multivariate analysis showed that factors such as platelet count,bilirubin levels,complicated with cardiovascular and cerebrovascular diseases,multiple organ dysfunction syndrome,and gastric tube intubation were independent prognostic risk factors for patients with CRE infection.Conclusion The main site of CRE infection is the lower respiratory tract in this hospital,and the risk factors affecting patient prognosis are clear.Targeted prevention and control measures should be developed.
作者
江冬萍
李艳霞
李虹
左素清
何莲芬
顾成武
JIANG Dong-ping;LI Yan-xia;LI Hong;ZUO Su-qing;HE Lian-fen;GU Cheng-wu(Suining Central Hospital,Suining Sichuan 629000,China)
出处
《中国消毒学杂志》
CAS
2024年第4期268-270,274,共4页
Chinese Journal of Disinfection
基金
四川省预防医学会医院感染预防与控制课题(SCGK202112)。
关键词
耐碳青霉烯肠杆菌
医院感染
预后
危险因素
carbapenem resistant Enterobacteriaceae
nosocomial infection
prognosis
risk factors
