摘要
目的探讨多囊卵巢综合征(PCOS)患者血清硫酸脱氢表雄酮(DHEA-S)、性激素结合球蛋白(SHBG)和17α-羟孕酮(17α-OHP)检测的临床意义。方法选取2020年1月1日—2023年3月8日上海市奉贤区奉城医院PCOS患者110例(PCOS组)、同期体检健康女性550名(正常对照组)。检测所有研究对象血清DHEA-S、SHBG和17α-OHP水平。采用多因素Logistic回归分析评估PCOS发生的危险因素。采用受试者工作特征(ROC)曲线评价DHEA-S、SHBG、17α-OHP诊断PCOS的效能。结果PCOS组血清DHEA-S和17α-OHP水平均显著高于正常对照组(P<0.01),SHBG水平显著低于正常对照组(P<0.01)。多因素Logistic回归分析结果显示,DHEA-S、SHBG和17α-OHP均是PCOS发生的危险因素[比值比(OR)值分别为3.546、0.931、5.742,95%可信区间(CI)分别为1.504~8.448、0.882~0.982、1.869~17.648,P<0.01]。DHEA-S、SHBG、17α-OHP单项检测和联合检测诊断PCOS的曲线下面积(AUC)分别为0.823、0.868、0.869、0.968。结论PCOS患者血清DHEA-S和17α-OHP水平显著升高,SHBG水平显著降低,三者联合检测在PCOS的辅助诊断中有较高的临床价值。
Objective To investigate the clinical roles of serum dehydroepiandrosterone sulfate(DHEA-S),sex hormone-binding globulin(SHBG)and 17 alpha-hydroxyprogesterone(17α-OHP)levels in patients with polycystic ovary syndrome(PCOS).Methods A total of 110 PCOS patients(PCOS group)and 550 healthy females(healthy control group)were enrolled from Fengcheng Hospital of Fengxian District from January 1,2020 to March 8,2023.Serum levels of DHEA-S,SHBG and 17α-OHP were determined.Multivariate Logistic regression analysis was used to evaluate the risk factors of PCOS.Receiver operating characteristic(ROC)curve was used to evaluate the efficacy of DHEA-S,SHBG and 17α-OHP in the diagnosis of PCOS.Results The serum DHEA-S and 17α-OHP levels in PCOS group were higher than those in healthy control group(P<0.01),and serum SHBG levels were lower than those in healthy control group(P<0.01).DHEA-S,SHBG and 17α-OHP were all risk factors for PCOS[odds ratios(OR)were 3.546,0.931 and 5.742,95%confidence intervals(CI)were 1.504~8.448,0.882~0.982,1.869~17.648,respectively,P<0.01].The areas under curves(AUC)of DHEA-S,SHBG and 17α-OHP for the diagnosis of PCOS were 0.823,0.868,0.869 and 0.968,respectively.Conclusions Serum DHEA-S and 17α-OHP levels in PCOS patients are increased,while SHBG levels are decreased.The combined determination of DHEA-S,SHBG and 17α-OHP levels in PCOS patients has high clinical value in the auxiliary diagnosis of PCOS.
作者
杜金龙
芦弘
DU Jinlong;LU Hong(Department of Clinical Laboratory,Fengcheng Hospital of Fengxian District,Shanghai 201411,China)
出处
《检验医学》
CAS
2024年第5期464-467,共4页
Laboratory Medicine
关键词
硫酸脱氢表雄酮
性激素结合球蛋白
17α-羟孕酮
多囊卵巢综合征
Dehydroepiandrosterone sulfate
Sex hormone-binding globulin
17 Alpha-hydroxyprogesterone
Polycystic ovary syndrome
