摘要
目的探讨血清Nesfatin-1水平在多囊卵巢综合征(PCOS)患者诊断中的临床价值,为临床诊治提供参考依据。方法以2014年1月-2015年12月期间来海南省第三人民医院做过检测性激素女性作为研究对象,选取其中158例PCOS患者作为试验组,选取116例诊治的健康女性作为对照组,测试两组患者的Nesfatin-1、黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)、空腹血糖(FBG)、空腹胰岛素(FINS),并将测试结果进行组间比较。结果试验组的患者LH、T、稳态模型胰岛素抵抗指数(HOMA-IR)与对照组相比明显提高,差异有统计学意义(均P<0. 05),FSH、血清Nesfatin-1水平与对照组相比较明显降低,差异有统计学意义(均P<0. 05)。结论 Nesfatin-1水平与PCOS常规的T、HOMA-IR呈负相关,与FSH呈正相关,提示检测PCOS患者血清Nesfatin-1水平有助于指导PCOS的诊断,该指标的检测具有重要的临床检测意义。
Objective To explore the clinical value of serum Nesfatin-1 level in diagnosis of polycystic ovary syndrome(PCOS),provide a reference basis for clinical diagnosis and treatment.Methods A total of 158 patients with PCOS were selected as experimental group from January 2014 to December 2015,and 116 healthy women were selected as control group,the women in the two groups underwent sex hormone detection.The levels of Nisfatin-1,luteinizing hormone(LH),follicle-stimulating hormone(FSH),testosterone(T),fasting blood glucose(FBG),and fasting insulin(FINS) in the two groups were detected and compared.Results Compared with control group,the levels of LH,T,and HOMA-IR in experimental group were statistically significantly higher than those in control group(P<0.05).The levels of serum FSH and Nesfatin in experimental group were statistically significantly lower than those in control group(P<0.05).Conclusion Nesfatin-1 level is negatively correlated with routine T and HOMA-IR in PCOS patients and positively correlated with FSH,detection of serum Nesfatin-1 level in patients with PCOS can help to guide diagnosis,the detection of Nesfatin-1 has important clinical significance.
作者
邓岳红
DENG Yue-Hong(The Third People's Hospital of Hainan Province,Sanya,Hainan 572000,China)
出处
《中国妇幼保健》
CAS
2019年第1期68-70,共3页
Maternal and Child Health Care of China
