摘要
目的:探讨牙周炎正畸患者治疗前后龈沟液高迁移率族蛋白B1(High mobility group box-1 protein,HMGB1)、可溶性细胞间黏附分子-1(soluble Intercellular adhesion molecule-1,sICAM-1)、白细胞介素-33(Interleukin-33,IL-33)、胸腺基质淋巴细胞生成素(Thymic stromal lymphopoietin,TSLP)水平动态变化及与牙周指标的关联性。方法:选择2019年1月-2021年8月笔者医院就诊的124例牙周炎正畸治疗患者作为研究对象进行回顾性分析,根据患者的治疗效果分为疗效良好(n=104)与疗效不良(n=20)。对比不同疗效患者的临床资料、牙周指标、龈沟液指标水平,分析牙周炎正畸患者疗效影响因素及龈沟液指标与牙周指标的关联性,并绘制工作特征曲线(ROC)评价龈沟液指标对患者预后的评估价值。结果:疗效良好患者治疗后牙周指标[菌斑指数(Plaque index,PLI)、出血指数(Bleeding Index,BI)、探诊深度(Probing depth,PD)]均低于疗效不良患者,差异有统计学意义(P<0.05);疗效良好患者治疗后龈沟液HMGB1、sICAM-1、IL-33、TSLP水平均低于疗效不良患者,差异有统计学意义(P<0.05);Logistic回归分析可知,治疗后牙周指标PLI、PD、BI及龈沟液HMGB1、sICAM-1、IL-33、TSLP水平均为牙周炎正畸患者治疗效果不良的影响因素(P<0.05);牙周炎正畸患者龈沟液HMGB1、sICAM-1、IL-33、TSLP水平均与牙周指标PLI、PD、BI呈正相关(P<0.05);术后龈沟液HMGB1、sICAM-1、IL-33、TSLP水平联合评估牙周炎正畸治疗患者疗效的AUC(0.934)最大,具有较高评估效能。结论:牙周炎正畸患者治疗前后龈沟液HMGB1、sICAM-1、IL-33、TSLP水平变化与其牙周状态关系密切,联合检测可为临床评估治疗效果并积极完善治疗方案提供参考。
Objective To investigate the dynamic changes of gingival crevicular fluid high mobility group box-1 protein(HMGB1),soluble intercellular adhesion molecule-1(sICAM-1),interleukin-33(IL-33),thymic stromal lymphopoietin(TSLP)levels before and after orthodontic treatment of periodontitis and their correlation with periodontal indexes.Methods A total of 124 patients undergoing orthodontic treatment with periodontitis in author's hospital from January 2019 to August 2021 were selected as the research objects.According to the treatment effect,they were divided into good curative effect(n=104)and poor curative effect(n=20).The clinical data,periodontal index and gingival crevicularfluid index levels of patients with different curative effects were compared,and the factors affecting the curative effect of orthodontic treatment of periodontitis and the correlation between gingival crevicularfluid index and periodontal index were analyzed.A receiver operating characteristic curve(ROC)was drawn to evaluate the evaluation value of gingival crevicular fluid indexes for the prognosis of patients.Results The periodontal indexes PLI,PD and BI of patients with good curative effect were lower than those with poor curative effect after treatment,and the difference was statistically significant(P<0.05).The levels of gingival crevicularfluid HMGB1,sICAM-1,IL-33 and TSLP in patients with good curative effect were lower than those with poor curative effect,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that the periodontal indexes PLI,PD,BI and the levels of gingival crevicularfluid HMGB1,sICAM-1,IL-33 and TSLP after treatment were all influential factors for the poor efficacy of orthodontic treatment of periodontitis(P<0.05).The levels of gingival crevicularfluid HMGB1,sICAM-1,IL-33,TSLP in patients with periodontitis orthodontic treatment were positively correlated with periodontal indexes PLI,PD,BI(P<0.05).The combined level of HMGB1,SICAM-1,IL-33 and TSLP in postoperative gingiva
作者
李洁
王倩
赵中华
郑迎秋
LI Jie;WANG Qian;ZHAO Zhonghua;ZHENG Yingqiu(Department of Stomatology,Tangshan Hongci Hospital,Tangshan 063000,Hebei,China;Department of Stomatology,Tangshan Vocational and Technical College,Tangshan 063000,Hebei,China;Department of Pediatric Stomatology,Tangshan Bochuang Stomatological Hospital,Tangshan 063000,Hebei,China)
出处
《中国美容医学》
CAS
2024年第6期132-136,共5页
Chinese Journal of Aesthetic Medicine
基金
中国金属协会冶金安全与健康分会健康卫生科研项目(编号:jkws202039)。
关键词
牙周炎
正畸
龈沟液
高迁移率族蛋白B1
白细胞介素-33
菌斑指数
探诊深度
periodontitis
orthodontic treatment
gingival crevicularfluid
high mobility group box-1 protein
interleukin-33
plaque index
probing depth
